IMPACT: Does the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in asymptomatic patients undergoing carotid artery stenting prior to cardiac surgery who are being pre-treated with either a 300 mg or a 600 mg loading dose of clopidogrel?
Phase 2
- Conditions
- carodit stenosis1000796310003216
- Registration Number
- NL-OMON31555
- Lead Sponsor
- R&D Cardiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
-patient > 18 years of age
-patient accepted for CABG and CAS
-temporal window for TCD available
Exclusion Criteria
-severe renal impairment, abnormal liver function, malignancy, febrile disorder, acute or chronic inflammatory disease and other diseases influencing platelet reactivity
-extreme tortuositas or calcification of the lesion
-patients with active bleeding or at high-risk of bleeding
-uncontrolled hypertension ( > 180/110 mmHg)despite optimal medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method