The Neural Underpinnings of Disinhibited Eating Behavior in Adolescents With and Without Obesity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Feeding Behavior
- Sponsor
- University of Colorado, Denver
- Enrollment
- 63
- Locations
- 1
- Primary Endpoint
- Disinhibited eating behavior
- Status
- Completed
- Last Updated
- 10 months ago
Overview
Brief Summary
The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.
Investigators
Eligibility Criteria
Inclusion Criteria
- •male or female
- •13-18 years-old
- •resident of Colorado
Exclusion Criteria
- •weigh less than 88 pounds or have a BMI% rank of \<10% for age and sex;
- •have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2);
- •have a physician's diagnosis of anorexia nervosa or bulimia nervosa;
- •currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications);
- •have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel);
- •experience symptoms of claustrophobia when in small or closed-off places;
- •are pregnant or plan to become pregnant
Outcomes
Primary Outcomes
Disinhibited eating behavior
Time Frame: study visit 2; 1.5 hours
Disinhibited eating behavior will be quantified via the kilocalories consumed during the test meal phase of the Eating in the Absence of Hunger laboratory protocol.
Brain function
Time Frame: brain imaging visit 1 (study visit 1); 30 minutes
Brain function will be quantified via the blood oxygen level-dependent (BOLD) signal in the hypothalamus, insula, anterior cingulate cortex, nucleus accumbens, amygdala, and superior and inferior frontal gyri, and connectivity between these brain regions.