Food Intake and the Adolescent Brain

Not Applicable

Recruiting

• Conditions: Brain; Adolescent; Feeding Behavior
• Interventions: Dietary Supplement: Energy Stimulus

• Registration Number: NCT04208256
• Lead Sponsor: University of Colorado, Denver

Brief Summary

The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-12-19
• Study First Submitted QC: 2019-12-19
• Study First Posted: 2019-12-23
• Study Start: 2019-12-30
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-11-30
• Primary Completion: 2024-09
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• male or female
• 13-18 years-old
• resident of Colorado

Read More

Exclusion Criteria

• weigh less than 88 pounds or have a BMI% rank of <10% for age and sex;
• have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2);
• have a physician's diagnosis of anorexia nervosa or bulimia nervosa;
• currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications);
• have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel);
• experience symptoms of claustrophobia when in small or closed-off places;
• are pregnant or plan to become pregnant

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Energy Surplus	Energy Stimulus	300ml fruit punch-flavored Glucola (75-gram\[g\], Azer Scientific) will be used as the energy surplus stimulus.
Energy Neutral	Energy Stimulus	Bottled water (300 ml) with added fruit punch-flavored non-nutritive sweetener (aspartame) will be used as the energy neutral stimulus.

Primary Outcome Measures

Name	Time	Method
Disinhibited eating behavior	study visit 2; 1.5 hours	Disinhibited eating behavior will be quantified via the kilocalories consumed during the test meal phase of the Eating in the Absence of Hunger laboratory protocol.
Brain function	brain imaging visit 1 (study visit 1); 30 minutes	Brain function will be quantified via the blood oxygen level-dependent (BOLD) signal in the hypothalamus, insula, anterior cingulate cortex, nucleus accumbens, amygdala, and superior and inferior frontal gyri, and connectivity between these brain regions.

Trial Locations

Locations (1)

University of Colorado; 🇺🇸 Aurora, Colorado, United States