To Assess Effects Of Letrozole In Infertility Treatment

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 70

Inclusion Criteria

Inclusion Criteria: Infertile female who are reffered to InVitro Fertillization Department of Jaame_Zanan Hospital candidates for InVitro fertillization or IntraCytoplasmic Sperm Injection; females aged over 30 years old; females diagnosed as poor ovarian responders. Females should have at least one of listing criterias to be classified as poor responders: previous cancled cycle due to poor ovarian response in an InVitro fertillization or IntraCytoplasmic Sperm Injection cycle (defined as having 3 or less oovocytes retrieved or serum estradiol less than 500 pg/ml), serum Follicle_Stimulating Hormone over 10 U/ml and age above 40 years old. Exclusion criterias are: Infertile females having all inclusion criterias but do not wish to be included in the project; females who show letrozole hypersensivity reactions or serious intolerable side effects of letrozole; females over 50 years old; having endocrine disorders such as thyroid dysfunction, hyperprolactinemia or diabetes;previous ovarian surgery; having a follicle larger than 10 mm at third day of menstural cycle; history of OHSS in previous ART cycle; uncorrected Mullerian anomaly; active renal or hepatic diseases.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oocytes retrieved number. Timepoint: at the end of ovarian stimulation cycle. Method of measurement: oovocyte retrieved containing both metaphase1 and 2 counted under microscopic examination by genetician.;Embrios transferred. Timepoint: at the end of cycle after 3-day growth of invitro. Method of measurement: counting embrios under microscopic examination by genetician.;Endometrial thickness. Timepoint: on the day of hCG administration. Method of measurement: measured by transvaginal sonograghy by gynecologist.;Total gonadotropin dose. Timepoint: after oovocyte puncture. Method of measurement: number of 75 IU gonadotropin ampules used till oovocyte puncture.

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate per cycle. Timepoint: at the end of project. Method of measurement: SPSS softeware.;Clinical pregnancy rate per emberio transfer. Timepoint: at the end of project. Method of measurement: SPSS softeware.;Implantation rate per cycle. Timepoint: at the end of project. Method of measurement: SPSS softeware.;Implantation rate per emberio transfer. Timepoint: at the end of project. Method of measurement: SPSS softeware.;Cancelation rate per cycle. Timepoint: at the end of project. Method of measurement: SPSS softeware.