Assessment the effect of combining letrozole and gonadotropin on the IVF / ICSI cycle success rate

Phase 3

• Conditions: Endometriosis.; Endometriosis, unspecified; N80.9

• Registration Number: IRCT20120104008611N12
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 94

Inclusion Criteria

Women with 18 to 35 year-old
Body mass index lower than 30 kg/m2
In her first IVF cycle
Without any uterine diseases
Sperm motility of at least 20% in sperm analysis
Anti-mullerin hormone greater than 1 ng/ml

Exclusion Criteria

Women who underwent letrozole or clomiphene therapy for induction ovulation
Sever endometriosis with DIE
Submucosal myoma with any size and intramural myoma greater than 3 cm was detected in transvaginal ultrasound
Withdraw to participation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The total prescribed dosage of Cinnal-f, and HMG. Timepoint: Once, at the trigger day. Method of measurement: Will be calculated by gynecologic.;The estradiol level. Timepoint: Once, at the trigger day. Method of measurement: Blood sample.;The oocyte number, and quality. Timepoint: Once, at puncture day. Method of measurement: According to the oocyte puberty degree, the oocyte quality will be determined.;The embryo quality. Timepoint: Once, after in vitro fertilization. Method of measurement: According to Gardner system.

Secondary Outcome Measures

Name	Time	Method
Biochemical pregnancy. Timepoint: Once, 14 days after fetus transfer. Method of measurement: Blood sampling.;Clinical pregnancy. Timepoint: Once, 6 to 8 weeks after fetus transfer. Method of measurement: Pregnancy sac observation in transvaginal ultrasound.