The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis
- Conditions
- Knee joint, Osteoarthritis, Muscle strength, Vitamin DKnie. Artrose, Spierkracht, Vitamine D
- Registration Number
- NL-OMON29469
- Lead Sponsor
- VU University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 178
Inclusion Criteria
Knee pain and at least 2 of the following 5 items: morning stiffness < 30 minutes, crepitations, bone sensitivity, bony enlargement of the joint margin, no palpable warmth
-Age > 55 and < 80 years
Exclusion Criteria
-Other forms of arthritis than OA (e.g. crystal arthropathy, septic arthritis, spondylarthropathy) identified by radiography and/or blood- and urine samples
-Absolute contra-indication for exercise therapy/strength training: resting systolic blood pressure of >200mgHG or diastolic blood pressure of >115 mgHG, acute myocardial infarction within the last 3 months, chest pain at rest/ before exercise, other severe cardiac diseases (e.g. present inflammations, symptomatic aortic stenosis, sever cardiac arrhythmias)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscle strength of the knee extensors and knee flexors.
- Secondary Outcome Measures
Name Time Method Knee pain, activity limitations (self-report and performance based), self-reported knee instability/falls and fractures, proprioception, inflammatory markers (i.e. C-reactive protein and Erythrocyte Sedimentation Rate), and depressive and anxious mood. Global perceived effect.