The effect of intensive muscle strength training and vitamin D supplementsin persons with knee osteoarthritis

• Conditions: knee osteoarthritisvitamin D deficiency; Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]

• Registration Number: EUCTR2014-000047-33-NL
• Lead Sponsor: VU University Medical Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02-24
• Last Update Posted: 31 March 2014

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

-Knee pain and at least 2 of the following 5 items: morning stiffness < 30 minutes, crepitations, bone sensitivity, bony enlargement of the joint margin, no palpable warmth
-Age = 55 and = 80 years
-Vitamin D deficiency: 25(OH)D level >15nmol/L and <50 nmol/L (in winter) or <70nmol/L (in summer)

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 70
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 150

Exclusion Criteria

-Other forms of arthritis than OA
-Absolute contra-indication for exercise therapy/strength training
-Inability to perform strength training program due to severe co-morbidity
-Use of vitamin D supplements >400 IU daily
-Living in a nursing home
-

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified