The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis

Phase 3

Completed

• Conditions: arthrosis deformans; cartilage wear; 10023213

• Registration Number: NL-OMON44546
• Lead Sponsor: Jan van Breemen Instituut

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 288

Inclusion Criteria

- Knee pain and at least 2 of the following 5 items: morning stiffness <
30 minutes, crepitations, bone sensitivity, bony enlargement of the joint
margin, no palpable warmth
- Age >= 55 and <= 80 years
- Vitamin D deficiency: 25(OH)D level >15nmol/L and <50 nmol/L (in
winter) or <70nmol/L (in summer);In addition, 68 knee OA patients with normal vitamin D levels will be included in order to study the effect of high versus low resistance strength training. The larger sample size (n=288) will lead to more statistical power. Patients with normal vitamin D levels will be randomized into either high or low resistance training, without supplementation with vitamin D or placebo.

Exclusion Criteria

- Other forms of arthritis than OA
- Absolute contra-indication for exercise therapy/strength training
- Inability to perform strength training program due to severe comorbidity
- Use of vitamin D supplements >800 IU daily
- Living in a nursing home

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Muscle strength of quadriceps and hamstrings (isokinetic test)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Knee pain, activity limitations (self-reported and performance-based), knee<br /><br>instability/falls and fractures (self-reported), proprioception (test),<br /><br>inflammatory factors in blood, and depressive and anxious mood (self-reported).<br /><br>Global perceived effect.</p><br>