Correlation Between External Jugular Venous and Superior Vena Cava Central Venous Blood Oxygen Saturation in Patient Under General Anesthesia

• Conditions: Central Venous Oxygen Saturation

• Registration Number: NCT04017182
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

After installation of central venous catheter in patients under general anesthesia, paired sample of superior vena cava central venous blood and right external jugular venous blood will be collected and send to central laboratory for venous blood gas analysis. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined as primary outcome.

Detailed Description

All patients age between 18-65 year old who undergoing surgery under general anesthesia and superior vena cava central venous catheter installation anticipated are eligible. The tips of superior vena cava central venous catheter was confirmed by Chest x-ray. Next 1 hour after skin incision, 1 ml of venous blood sample is taken from superior vena cava central venous catheter of right external jugular vein then send to central laboratory for venous blood gas analysis. The demographic data will be recorded. Correlation between superior vena cava central venous blood and right external jugular venous blood oxygen saturation will be determined the primary outcome and partial pressure of carbon dioxide will be determined as a secondary outcome.

Study Timeline

• Study First Submitted: 2019-07-04
• Study First Submitted QC: 2019-07-11
• Study First Posted: 2019-07-12
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-05
• Last Update Posted: 2021-03-09
• Study Start: 2021-04-01
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Written consent obtained from patient or next of kin a day before operation date
• Patient age between 18-65 years old undergoing syrgery under general anesthesia
• Superior vena cava central venous catheter anticipated for CVP mesurement, innotropic or vasopressor administration,pulmonary artery catheter insertion route
• Anticipated right external jugular venous sampling time less than 5 minutes
• The site of blood sample collection easily access during operation

Exclusion Criteria

• No jugular central venous catheter installation or other route selected
• Duration of paired sample collection more than 10 minutes
• Can not collected blood sample from right external jugular vein within 3 attemps
• The site of blood sample collection difficulty access during operation
• Pateint or next of kin refuse to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of venous oxygen saturation	1 hour	Correlation of venous oxygen saturation between external jugular vein and superior vena cava

Secondary Outcome Measures

Name	Time	Method
Correlation of venous partial pressure of carbon dioxide	1 hour	Correlation of venous partial pressure of carbon dioxide between external jugular vein and superior vena cava
Relationship between superior vena cava central venous and external jugular venous oxygen saturation	1 hour	Linear regression to determine prediction equation between superior vena cava oxygen saturation and external jugular vein oxygen saturation

Trial Locations

Locations (1)

Department of Anesthesiology, Ramathibodi Hospital; 🇹🇭 Bankok, Bangkok, Thailand