Effects of Reducing Prolonged Sitting on the Endothelial Function in Overweight/Obese Adults

Not Applicable

Recruiting

• Conditions: Endothelial function; Metabolic and Endocrine - Normal metabolism and endocrine development and function; Cardiovascular - Normal development and function of the cardiovascular system; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12616000578404
• Lead Sponsor: Professor David Dunstan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Overweight and obese participants aged between 35-75 years will be recruited from the local community. Eligibility will be based on having a BMI more than or equal to 25 but less than 40 kg/m2, and English speaking.

Exclusion Criteria

Exclusion criteria include pregnancy, employment in a non-sedentary occupation i.e. less than 5 hours sitting per day, regularly engaged in moderate-intensity exercise more than or equal to 150 min per week for more than 3 months, diagnosed diabetes, use of glucose/lipid lowering/antidepressant medications, current smoker, pre-menopausal or menopausal women, known physical activity contraindications, major illness/physical problems (acute or chronic) that may limit their ability to perform the activity bouts

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endothelial function of superficial femoral artery using high-resolution Doppler ultrasound.[On the trial days, assessed at baseline, 0.5, 1.5, 2.5, 3.5 and 4.5 hours for the superficial femoral artery];Endothelial function of brachial artery using high-resolution Doppler ultrasound.[On the trial days, assessed at baseline and 5 hours for the brachial artery.]