nderstanding the negative effects of prolonged sitting: investigating the impact on musculoskeletal discomfort and cardiovascular parameters

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus; Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12616000513415
• Lead Sponsor: Professor David Dunstan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-04-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Participants will be overweight/obese, based on having a BMI between 25 kg/m2 and 40 kg/m2, previous diagnosis of type 2 diabetes greater than 3 months, and be english speaking.

Exclusion Criteria

Conditions for exclusion are: diagnosis of type 2 diabetes for less than 3 months; unable to sit for prolonged periods due to musculoskeletal pain; pregnancy; employment in a non-sedentary occupation; currently watching less than 3 hours of television per day; regularly engaged in moderate-intensity exercise for greater than or equal to 150 min/week for greater than 3 months; use of glucose/lipid lowering/antidepressant medications; pre-menopausal or menopausal women; and major illness/physical problems.
These exclusion criteria are necessary to ensure our participants fall within the demographic in which the risk of cardiovascular and diabetic complications due to sedentary behaviour are elevated. This is the target group for future interventions in whom breaks from daily prolonged sitting are likely to be of most benefit.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Musculoskeletal discomfort (assessed by visual analogue scale)[Every 10 minutes whilst participant is seated. Normally completed within 1 minute.];Muscle activity measured using surface electromyography from muscles involving sitting (upper trapezius, lumbar erector spinae, quadriceps, hamstrings)[Every 3 minutes for a period of 15 seconds whilst the participant is seated];Spinal posture measured via electromagnetic motion tracking[Recorded every 3 minutes for a period of 15 seconds whilst the participant is seated]

Secondary Outcome Measures

Name	Time	Method
postprandial glucose response, continuous assessment measured with a Continuous Glucose Monitor Sensor (CGMS)[Measured for 5 hours starting 10 minutes prior to breakfast meal consumption];Spontaneous Baroreflex (with ECG and continuous BP finapress)[Assessed at 30 minute intervals whilst seated for a period of 10 minutes];Muscle sympathetic nervous activity (MSNA) using microneurography. One microelectrode is inserted under the skin near the head of the fibula, and the other on top of the peroneal nerve.[From baseline to 2-hours post-meal]