The acute effects of sitting and breaking-up sitting on cognitive function in healthy elderly.

Completed

• Conditions: Sedentary behaviour; cognitive decline; 10012272; 10024450

• Registration Number: NL-OMON46706
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 22

Inclusion Criteria

- 70-90 years of age
- Mentally able to give informed consent
- Adequate visual and auditory acuity to complete neuropsychological testing
- Scores on the MoCA of *24
- Able to sit for three hours uninterruptedly (no urinary urgency problems)

Exclusion Criteria

- Persons who are not physically able to perform light-intensity physical activity such as standing and walking.
- Diagnosis of AD, any other type of dementia or MCI
- History of familial early-onset dementia; first or second degree family member diagnosed with dementia aged *55 years of age
- Enrolment in any investigational drug study
- Diagnosis of or drug use for any major psychiatric disorder (a clinical diagnosis of major depressive disorder, bipolar or schizophrenia) e.g. Anti-depressants, anti-psychotics, lithium
- Drug use that affects alertness from the evening before the measurement, till the end of the measurement day, e.g. Psycho pharmacy e.g. benzodiazepines (oxazepam, temazepam, zolpidem), over-the-counter medication (melatonine, valeriane)
- Past history or MRI evidence of brain damage, including significant trauma, stroke, hydrocephalus, mental retardation, or serious neurological disorder
- Vigorously active for more than 3 hours per week (based on SQUASH questionnaire)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameter of this study is the difference between the conditions<br /><br>between the change in cognitive measures, as measured by the TAP test before<br /><br>and after the three hour periods. Alertness, working memory, and flexibility<br /><br>will be measured. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Cerebrovascular autoregulation will serve as an intermediate outcome. Changes<br /><br>in cerebral autoregulation and cerebrovascular reactivity will be measured<br /><br>before and after each of the 3 hour conditions as well. </p><br>