Lung Tissue Research Consortium

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Interstitial Lung Disease
• Interventions: Procedure: Lung biopsy/lobectomy

• Registration Number: NCT02988388
• Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary

The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the LTRC. Collections of specimens will be linked to individual clinical data appropriate to the particular disease. The primary goal of the LTRC is to identify participants with suspected lung cancer or metastatic disease who are willing to provide informed consent for research use of their specimens and data. Secondarily, the LTRC investigators intend to collect clinical data, limited exposure data, physiologic studies, and radiographic studies from these participants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-07
• Study First Submitted QC: 2016-12-07
• Study First Posted: 2016-12-09
• Study Start: 2017-02-23
• Status Verified: 2017-08
• Primary Completion: 2019-01-28
• Study Completion: 2019-02-21
• Last Update Submitted: 2019-03-07
• Last Update Posted: 2019-03-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 247

Inclusion Criteria

• Adults ages 21 or older who are undergoing lung surgery for suspected malignancy or metastases.

Exclusion Criteria

• Diagnosis of cystic fibrosis or pulmonary hypertension.
• Any other condition that, in the judgment of the investigator, precludes participation.
• Failure to obtain written consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Lung biopsy/lobectomy	Lung biopsy/lobectomy	Adults ages 21 or older who are undergoing lung surgery for suspected malignancy or metastases.

Primary Outcome Measures

Name	Time	Method
Clinical diagnosis	Two months following surgery	A final diagnosis of the participant's lung disease will be rendered by the clinical center PI.

Trial Locations

Locations (4)

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Mayo Clinic Rochester; 🇺🇸 Rochester, Minnesota, United States

Temple University; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States