Effects of energy distribution across three main daily meals during prolonged sitting on the regulation of blood glucose

Not Applicable

• Conditions: Type 2 diabetes; Overweight/obesity; Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12615001216505
• Lead Sponsor: Professor John Hawley

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-11-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Presenting as pre-diabetic - [by having a fasting blood glucose greater than 5.9 mmol/L and/or a 2 hour oral glucose tolerance test blood glucose between 7.8 mmol/L and 11.0 mmol/L]
Being overweight or obese - [body mass idex (BMI) greater than 25 kg/m2 and less than 45 kg/m2

Exclusion Criteria

Participants will be excluded on the basis of: pregnancy; use of carbohydrate or lipid-lowering medication if it has been commenced within 3 months; bariatric surgery (gastric bypass or banding); employment in a non-sedentary occupation; currently watching less than 3 hours of television or computer use per day; regularly engaged in moderate-intensity exercise for greater than 150 min/week for more than 3 months; major illness/injury (acute or chronic), current smoker or use of nicotine replacement therapy; or physical or major illness/physical problems (acute or chronic) that may limit their ability to participate in the intervention

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in blood glucose area under the curve using subcutaneous continuous blood glucose monitors, validated with serial finger prick samples.[Pre to post intervention (i.e. from insertion the night before trial day to 8 am on the day after trial day), including the 4-h postprandial periods, with finger prick samples at 1 h post insertion (i.e. 5 pm of the day before), prior to breakfast, prior to lunch, prior to dinner and the morning after the trial.];Change in blood glucose area under the curve using venous plasma samples obtained throughout a day[Measured from 8 am to 6 pm inclusively, every hour as well as 30 min post meals, to calculate mean glucose, total area under the curve (AUC), and postprandial incremental AUC in the 4-h period post meals.]