The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Phase 4

• Conditions: Apoptosis; Liver Surgery
• Interventions: Procedure: Liver surgery

• Registration Number: NCT01267786
• Lead Sponsor: Aretaieio Hospital

Brief Summary

The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-12
• Study Start: 2010-12
• Study First Submitted: 2010-12-28
• Study First Submitted QC: 2010-12-28
• Last Update Submitted: 2010-12-28
• Study First Posted: 2010-12-29
• Last Update Posted: 2010-12-29
• Primary Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients undergoing liver surgery

Exclusion Criteria

• ASA IV, Cardiovascular diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
desflurane	Liver surgery	1 MAC intraoperatively
Sevoflurane	Liver surgery	1MAC intraoperatively

Primary Outcome Measures

Name	Time	Method
Oxidotic stress after hepatectomy.	5 d postop.	Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring

Secondary Outcome Measures

Name	Time	Method
Liver and renal dysfunction	5 d	liver and renal impairment due to ischemic injury

Trial Locations

Locations (1)

Aretaieio Hospital; 🇬🇷 Athens, Attica, Greece