Evaluating the Effect of Desflurane Versus Sevoflurane With Recent Biomarkers of Renal and Hepatic Function in Laparoscopic Cholecystectomy Patients: A Prospective Randomized Double Blinded Study
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- Postoperative Complications
- Sponsor
- Theodor Bilharz Research Institute
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Change in serum Neutrophil gelatinase-associated lipocalin (NGAL)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Studying the effects of both inhalational anesthetics desflurane and sevoflurane on hepatic integrity and renal function, guided by recent blood and urine biomarkers in patients undergoing laparoscopic cholecystectomy surgery.
Investigators
khalda Galal Moustafa
Principal Investigator
Theodor Bilharz Research Institute
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) Class: I\&II.
- •Elective laparoscopic cholecystectomy.
- •Age: 25-55 years.
- •Gender: Both male and female.
- •Body Mass Index (BMI): 18.5-24.9 km2-(Normal weight).
Exclusion Criteria
- •Extremes of age.
- •Abnormal hepatic function by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values outside the normal range.
- •Abnormal renal function by blood urea nitrogen (BUN) and creatinine above the normal ranges.
- •Hypertension, unstable angina pectoris or myocardial infarction within the last six months.
- •Pregnancy and lactation.
- •Bronchial asthma.
- •Drug allergies.
- •Alcohol or drug addiction.
- •General anesthesia within the last three months.
Arms & Interventions
Sevoflurane
This group will receive sevoflurane as the maintenance inhalational anesthetic.
Intervention: Sevoflurane
Sevoflurane
This group will receive sevoflurane as the maintenance inhalational anesthetic.
Intervention: Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Desflurane
This group will receive desflurane as the maintenance inhalational anesthetic.
Intervention: Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Desflurane
This group will receive desflurane as the maintenance inhalational anesthetic.
Intervention: Desflurane
Outcomes
Primary Outcomes
Change in serum Neutrophil gelatinase-associated lipocalin (NGAL)
Time Frame: a change from baseline NGAL serum level at 6 hours
Renal Biomarker
Secondary Outcomes
- Change in serum Arginase(Baseline, first hour, six hours, after 24 hours)
- Change in serum Cystatin-c(Baseline, first hour, six hours, after 24 hours)
- Change in urine Interleukin-18(Baseline, first hour, six hours, after 24 hours)
- Change in urine Netrin-1(Baseline, first hour, six hours, after 24 hours)
- Change in urine Kidney Injury Molecule(Baseline, first hour, six hours, after 24 hours)
- Change in urine Alpha-Glutathione S-Transferase(Baseline, first hour, six hours, after 24 hours)