Role of Volatile Anesthetics for Hepatic Protection

Not Applicable

Completed

• Conditions: Reperfusion Injury

• Registration Number: NCT00516711
• Lead Sponsor: University of Zurich

Brief Summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Detailed Description

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Study Timeline

• Study Start: 2006-03
• Status Verified: 2007-08
• Study First Submitted: 2007-08-14
• Study First Submitted QC: 2007-08-14
• Study First Posted: 2007-08-15
• Primary Completion: 2007-12
• Study Completion: 2007-12
• Last Update Submitted: 2010-09-14
• Last Update Posted: 2010-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Older than 18 years of age
• Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria

• Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
• Liver cirrhosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)

Trial Locations

Locations (1)

University Hospital of Zurich; 🇨🇭 Zurich, Switzerland