Organ Protection With Sevoflurane Postconditioning

Not Applicable

Completed

• Conditions: Hepatectomy
• Interventions: Drug: Sevoflurane

• Registration Number: NCT00518908
• Lead Sponsor: University of Zurich

Brief Summary

Organ protection, volatile anesthetics, postconditioning, hepatic surgery

Detailed Description

This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.

Study Timeline

• Study First Submitted: 2007-08-20
• Study First Submitted QC: 2007-08-20
• Study First Posted: 2007-08-21
• Study Start: 2008-01
• Primary Completion: 2010-08
• Study Completion: 2010-09
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-18
• Last Update Posted: 2011-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Sevoflurane for pharmacological postconditioning
Propofol	Sevoflurane	Anesthesia maintenance with propofol instead of Sevoflurane postconditioning

Primary Outcome Measures

Name	Time	Method
Liver transaminase AST	Postoperative phase until discharge	Peak value

Secondary Outcome Measures

Name	Time	Method
ALT peak value	Postoperative phase until discharge
Course of transaminases	From the day before surgery, to 6 hours after surgery, up to postoperative day 7
Need for prolonged intensive care unit stay (>24 hours)	Postoperative phase until discharge
Postoperative complications	Postoperative phase until discharge
Length of hospital stay	Postoperative phase until discharge

Trial Locations

Locations (1)

University Hospital of Zurich; 🇨🇭 Zurich, Switzerland