Effect of Gluten free diet on metabolic control and anthropometric parameters in type-1 diabetics with celiac disease
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Type 1 Diabetics patient with celiac disease
- Registration Number
- CTRI/2018/06/014508
- Lead Sponsor
- A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1.Patients with Type 1 diabetes attending Diabetes of Young Clinic or admitted in Endocrinology Ward of AIIMS and
2.Patients with celiac disease diagnosed on the basis of positive tTG Ab on screening and duodenal biopsy suggestive of celiac disease on the basis of modified marsh criteria or patients with positive tTG Ab level >200 IU/ml with normal duodenal biopsy
Exclusion Criteria
1.Chronic diarrhea defined as diarrhea persisting more than 4 weeks in adults and more than 3 months in children.
2.Recurrent diarrhea defined as frequent episodes of acute diarrhea each lasting less than 2 weeks.
3.Severe anemia defined as hemoglobin less than 8 g/dl as measured by automated analyzer
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency of hypoglycemic episodes defined as blood glucose value of less than 70 mg/dl as measured by self monitoring of blood glucose (SMBG) at 6th month of starting gluten free diet (GFD) in patients with type-1 diabetes (type-1 DM) and celiac disease as compared with the group of patients with type -1 DM and celiac disease not receiving GFDTimepoint: 6 month
- Secondary Outcome Measures
Name Time Method 1.To study the effects of gluten free diet on anthropometric parameters including height, weight and body mass index in patients with type-1 diabetes and celiac disease. <br/ ><br>2.To study the effects of gluten free diet on glycemic control including glycosylated hemoglobin levels and insulin dose requirement, in patients with type-1 diabetes and celiac disease. <br/ ><br>3.To study the effects of gluten free diet on bone mineral homeostasis in patients with type-1 diabetes and celiac disease <br/ ><br>Timepoint: 3months, 6months, 9months and 1 yr