Effects of Childhood Trauma on Stress Reactivity: an MR study
- Conditions
- effecten van stress op MRS metabolieten bij jeugdtraumaChildhood-trauma associated psychiatric disorders
- Registration Number
- NL-OMON40873
- Lead Sponsor
- Psychiatrie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
- Male sex
- Age between 18 and 40 years old
- Either low or high levels of childhood maltreatment
General exclusion criteria:
- Incapability of giving informed consent
- Lack of fluency in the Dutch language or speech impairments
- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
- Use of medication which might influence the stress response, such as psychotropics, beta blockers, ACE inhibitors and any hormonal treatment.
- Major medical history including history of closed or open head injury.
- Acute minor medical illness within the three weeks prior to testing
- History of any psychiatric, neurological or endocrine disorder including claustrophobia and alcohol abuse or dependence
- Self-reported current smoking in the last 2 weeks
- Self-reported current or past drug use in the last 2 weeks
- Ferrous objects in or around the body according to default checklist present at 7T scanner (version defined by METC protocol 07-235: *MRI development for 7T (and lower field strengths)* ;Acute exclusion criteria on 2nd and 3rd visit:
- Any acute inflammatory disease
- Physical exertion within the last 2 hours
- Drink other than water or any food within the last 2 hours
- Any alcohol use in the last 24 hours
- Positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine and opiates)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary parameter: Concentrations of glutamate, glutamine, GABA, choline, NAA,<br /><br>creatine, myoinositol and lactate as measured by 7T-MRS.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters:<br /><br>- Basal and stress-induced levels of cortisol, alpha amylase, and heart rate.<br /><br>- Perceived stress levels.<br /><br>- (Epi)genetic variation in a limited number of stress genes.<br /><br>- Plasma GABA levels</p><br>