Haemodynamic Effects Of Intravenous Paracetamol In Patients With Chronic Liver Disease Undergoing Liver Transplantation: A Pilot Study

Phase 4

Completed

• Conditions: Chronic Liver Disease; Liver Transplantation; Anaesthesiology - Anaesthetics; Surgery - Surgical techniques; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12615001132538
• Lead Sponsor: Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-10-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Adult surgery patients (age >18 years)
2. Patients with chronic liver disease requiring liver transplantation

Exclusion Criteria

Paracetamol use 24 hours prior to surgery (in paracetamol only or in combination therapy)

Pregnancy

Chronic renal impairment (creatinine >250 umol/L)

Chronic liver disease (ALT >200IU/L)

Morbid obesity (BMI >35kg/m2)

Known allergic reaction to IV paracetamol

Consumption of caffeine (e.g. coffee or energy drinks) <10 hours prior to surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified