Interest of the T2 * Sequence in MRI for the Diagnosis of Migraine Aura in the Acute Phase.

Phase 4

Completed

• Conditions: Migraine Aura
• Interventions: Other: telephone consultation; Combination Product: MRI; Diagnostic Test: MRI control

• Registration Number: NCT03689361
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

investigators hypothesize that T2 \* vein abnormalities are frequent and are specific to the migraine aura.

Detailed Description

The diagnosis of migraine aura is now based solely on clinical criteria and the assertion of the diagnosis on these clinical criteria alone proves difficult in the acute phase. Added to this difficulty, the symptomatology of a migraine aura can sometimes be similar to that of a stroke, so a diagnosis can be poorly established, resulting in poor patient care. The possibility of making the positive diagnosis of migraine aura on a routine MRI sequence, T2 \*, would be an important advance for the management of these patients

Study Timeline

• Study First Submitted: 2018-09-20
• Study First Submitted QC: 2018-09-27
• Study First Posted: 2018-09-28
• Study Start: 2018-12-22
• Primary Completion: 2020-10-11
• Study Completion: 2020-12-11
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-02
• Last Update Posted: 2021-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients aged 18 to 55 years

• Admitted to the Neuro-Vascular Intensive Care Unit for Acute Focused Neurological Symptoms and MRI

  • less than 4 hours 30 minutes after onset of symptoms if symptoms persist during admission
  • less than two hours after the disappearance of symptoms if the patient arrives asymptomatic

• Affiliated to a social protection scheme.

• Having given their informed consent

Exclusion Criteria

• Patients with neurological signs pointing to vertebrobasilar localization (vertigo, diplopia) or with a disorder of consciousness
• Presence of recent explanatory abnormalities on the MRI to make a diagnosis compatible with the initial neurological symptomatology (visible stroke in diffusion, cerebral hemorrhage, tumor, arteriovenous malformations).
• Potential strong cause of stroke known or discovered at the arrival of the patient, in particular stenosis of a cervical or intracranial artery upstream of the cerebral zone may correspond to the symptoms and emboligenic heart disease type atrial fibrillation.
• Pregnant women - Patients with a contraindication for MRI.
• Patients benefiting from a system of legal protection (tutelage,

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
without migraine aura	telephone consultation	patient without migraine aura detected by MRI, then telephone consultation 3 month after
with migraine aura.	MRI control	patient with migraine aura detected by MRI, then MRI control 3 month after
with migraine aura.	MRI	patient with migraine aura detected by MRI, then MRI control 3 month after

Primary Outcome Measures

Name	Time	Method
frequency of the presence of visible brain vein abnormalities	Day 0	visible brain vein abnormalities on T2 \* sequences MRI ,

Secondary Outcome Measures

Name	Time	Method
asymmetry of visualization of the 3 intracranial arteries in MRI	Day 0	in MRI TOF
perfusion parameters	Day 0	in MRI , Overall visual assessment: presence or absence of hypoperfusion (presence or not in each anterior, middle and posterior territory) each lobe: Frontal, Temporal, Parietal, Occipital)

Trial Locations

Locations (1)

Hôpital Pierre Paul Riquet - CHU de Toulouse; 🇫🇷 Toulouse, France