A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
- Conditions
- Squamous Cell Carcinoma of the Head and Neck
- Interventions
- Radiation: Intensity Modulation Radiation Therapy (IMRT)Drug: Placebo
- Registration Number
- NCT04459715
- Brief Summary
The primary objective of the study is to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 730
- Eastern Cooperative Oncology Group performance status (ECOG PS) 0 or 1
- Histologically confirmed diagnosis of previously untreated Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN) participant (stage III, IVa or IVb according to the American Joint Committee on Cancer(AJCC))/Classification of malignant tumors: T=size of the primary tumor, N=regional lymph node involvement, M=distant metastasis (TNM) Staging System, 8th Edition.) suitable for definitive ChemoRadiotherapy (CRT), of at least one of the following sites: oropharynx, hypopharynx and larynx
- For OroPharyngeal Cancer (OPC) participants, primary tumors must be human papillomavirus (HPV)-negative as determined by p16 expression using immunohistochemistry
- Evaluable tumor burden (measurable and/or non-measurable tumor lesions) assessed by computed tomography scan (CT-scan) or magnetic resonance imaging (MRI), based on Response evaluation criteria in solid tumors (RECIST) version 1.1
- Peripheral neuropathy less than (<) grade 2
- Adequate hematologic, renal and hepatic function
- Other protocol defined inclusion criteria may apply
- Primary tumor of nasopharynx, paranasal sinuses, nasal or oral cavity, salivary, thyroid or parathyroid gland pathologies, skin or unknown primary site
- Metastatic disease (stage IVc as per AJCC/TNM, 8th Ed.)
- Prior definitive or adjuvant Radiotherapy (RT) and/or radical surgery to the head and neck region which may jeopardize the primary tumor irradiation plan, or any other prior SCCHN systemic treatment, including investigational agents
- Documented weight loss of >10% during the last 4 weeks prior to randomization (unless adequate measures are undertaken for nutritional support), OR plasmatic albumin < 3.0 g/dL. No albumin transfusions are allowed within 2 weeks before randomization
- Known allergy to Xevinapant (Debio 1143), cisplatin, carboplatin, other platinum-based agent or any excipient known to be present in any of these products or in the placebo formulation
- other protocol defined exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Xevinapant (Debio 1143) Xevinapant (Debio 1143) Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Xevinapant (Debio 1143) Monotherapy period (Cycles 4-6): • Xevinapant (Debio 1143) Xevinapant (Debio 1143) Cisplatin Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Xevinapant (Debio 1143) Monotherapy period (Cycles 4-6): • Xevinapant (Debio 1143) Xevinapant (Debio 1143) Intensity Modulation Radiation Therapy (IMRT) Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Xevinapant (Debio 1143) Monotherapy period (Cycles 4-6): • Xevinapant (Debio 1143) Placebo Cisplatin Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Matched placebo Monotherapy period (Cycles 4-6): • Matched placebo Placebo Intensity Modulation Radiation Therapy (IMRT) Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Matched placebo Monotherapy period (Cycles 4-6): • Matched placebo Placebo Placebo Participants will receive: Concomitant chemo-radiation therapy period (Cycles 1-3): * Radiotherapy * Cisplatin * Matched placebo Monotherapy period (Cycles 4-6): • Matched placebo
- Primary Outcome Measures
Name Time Method Event-Free Survival (EFS) Up to 5 years EFS is the time from the date of randomization to the date of first record of disease progression or death.
- Secondary Outcome Measures
Name Time Method Objective Response Rate (ORR) Up to 5 years ORR defined as proportion of participants with complete response (CR) or partial response (PR) by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, as assessed by Blinded Independent Review Committee (BIRC).
Complete Response Rate (CRR) Up to 5 years CRR defined as proportion of participants with complete response (CR) as assessed by Blinded Independent Review Committee (BIRC).
Overall survival (OS) Up to 5 years OS is the time from randomization to death due to any cause.
Changes from Baseline in Global Health Status/Quality of Life (GHS/QoL) and Fatigue Symptom Prior to the first dose of study treatment (Baseline) and at the time of last follow-up (Up to 5 years) Change from baseline in GHS/QoL and Fatigue Symptom using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30)
Changes from Baseline in Swallowing and Pain Symptoms Prior to the first dose of study treatment (Baseline) and at the time of last follow-up (Up to 5 years) Change from baseline in swallowing, and pain symptoms using the EORTC Head and Neck Questionnaire (EORTC QLQ-H\&N35)
Progression-Free Survival (PFS) Up to 5 years PFS is the time from randomization to the earliest between PFS event or End of Study (EOS)
Locoregional Control (LRC) From randomization to the earliest between PFS event (progression at the site of the primary tumor or the locoregional lymph nodes) or EOS (Up to 5 years) Duration of Response (DOR) Up to 5 years Duration of response (DoR) defined as the time from the first evidence of response (partial or complete, as assessed by the BIRC according to RECIST v1.1) to the first occurrence of progression (radiological or clinical, as assessed by the BIRC) or death from any cause.
Number of Participants with Radical Salvage Surgery Up to 5 years Time to Subsequent Systemic Cancer Treatments Up to 5 years Safety and Tolerability as assessed by incidence and severity of Adverse Events (AEs), Serious Adverse Events (SAEs), AEs of Special Interest (AESIs), Changes in Laboratory Values, Vital Signs, Electrocardiogram (ECGs) and Extent of Exposure From signed informed consent to EOS (within 6.8 years)
Trial Locations
- Locations (285)
Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology
🇺🇸Fort Wayne, Indiana, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Medical center of Yuriy Spizhenko, Soborna Vulytsia
🇺🇦Kyiv, Ukraine
CHU UCL Namur Site Sainte Elisabeth
🇧🇪Namur, Belgium
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
Centre Hospitalier de l'Ardenne (CHA)
🇧🇪Libramont, Belgium
Hopital de Jolimont, Rue Ferrer
🇧🇪La Louvière, Belgium
A.Z. Nikolaas
🇧🇪Sint-Niklaas, Belgium
UZ Leuven, Radiotherapy & Oncology
🇧🇪Leuven, Belgium
Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE
🇵🇹Coimbra, Portugal
Institute of Clinical Oncology
🇬🇪Tbilisi, Georgia
Centro Clinico Academico
🇵🇹Braga, Portugal
Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie
🇨🇭Bern, Switzerland
Chang-Gung Memorial Hospital-Kaohsiung
🇨🇳Kaohsiung City, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital (VGHTP)
🇨🇳Taipei, Taiwan
Kaohsiung Medical University Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital
🇨🇳Taoyuan City, Taiwan
Centro Hospitalar Universitário Lisboa Norte
🇵🇹Lissabon, Portugal
Centre Hospitalier Universitaire Vaudois Lausanne
🇨🇭Lausanne, Switzerland
China Medical University Hospital
🇨🇳Taichung, Taiwan
Centro Hospitalar de Vila Nova de Gaia/Espinho
🇵🇹Porto, Portugal
Centro Hospitalar Universitario São João
🇵🇹Porto, Portugal
Hopitaux Universitaires de Geneve
🇨🇭Geneve, Switzerland
Zhejiang Province Cancer Hospital
🇨🇳Hangzhou, China
Jilin Cancer Hospital
🇨🇳Changchun, China
Xiangya Hospital Central South University
🇨🇳Changsha, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Affiliated Tumor Hospital of Guangxi Medical University
🇨🇳Nanning, China
Lin Yi Cancer Hospital
🇨🇳Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, China
Shanghai Ninth People's Hospital
🇨🇳Shanghai, China
GZA Sint-Augustinus
🇧🇪Wilrijk, Belgium
University of Colorado at Denver and Health Sciences Center
🇺🇸Aurora, Colorado, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Wollongong Hospital
🇦🇺Wollongong, Australia
Gettysburg Cancer Center
🇺🇸Gettysburg, Pennsylvania, United States
Universitätsklinik für Innere Medizin III der PMU
🇦🇹Salzburg, Austria
Medical University of Vienna, Department of Medicine I, Division of Oncology
🇦🇹Vienna, Austria
University Hospital Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Ashford Cancer Centre Research, Tennyson Centre
🇦🇺Adelaide, Australia
Medical University of South Carolina- Hollings Cancer Center
🇺🇸Charleston, South Carolina, United States
Hospital de Caridade de Ijui, Avenida David Jose Martins
🇧🇷Ijuí, Brazil
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde
🇦🇹Graz, Austria
Landeskrankenhaus Salzburg
🇦🇹Salzburg, Austria
Grand Hopital de Charleroi
🇧🇪Charleroi, Belgium
CHU Montréal
🇨🇦Montreal, Canada
Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer
🇧🇷Porto Alegre, Brazil
Peter MacCallum Cancer Centre
🇦🇺Melbourne, Australia
Hospital Aleman
🇦🇷Buenos Aires, Argentina
University South Hospital
🇺🇸Ann Arbor, Michigan, United States
St Vincents Hospital Melbourne
🇦🇺Fitzroy, Australia
London Regional Cancer Program, London Health Sciences Centre
🇨🇦London, Canada
Instituto Medico Especialazado Alexander Fleming
🇦🇷Buenos Aires, Argentina
St Vincents Hospital
🇦🇺Darlinghurst, Australia
Evex Hospitals Oncology Center
🇬🇪Kutaisi, Georgia
JSC "Evex Hospitals"
🇬🇪Tbilisi, Georgia
CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie
🇩🇪Berlin, Germany
Istituto di Candiolo IRCCS
🇮🇹Candiolo, Italy
Uzsoki Utcai Korhaz Onkologiai Osztaly
🇭🇺Budapest, Hungary
Universitätsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Petz Aladár Megyei Kórház Onkoradiológiai Osztály
🇭🇺Győr, Hungary
Attikon University Hospital
🇬🇷Athens, Greece
Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle
🇮🇹Cuneo, Italy
Universitaetsklinikum Regensburg
🇩🇪Regensburg, Germany
Research Fund of the Hadassah Medical Organization
🇮🇱Jerusalem, Israel
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet
🇭🇺Pécs, Hungary
Institut Gustave Roussy - Service de radiotherapie
🇫🇷Villejuif, France
Charité - Universitätsmedizin Berlin Campus Virchow
🇩🇪Berlin, Germany
New Hospitals
🇬🇪Tbilisi, Georgia
Centre Oscar Lambret
🇫🇷Lille, France
Centre Jean Perrin CLCC
🇫🇷Clermont Ferrand, France
Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine
🇬🇪Tbilisi, Georgia
LEPL First University Clinic of Tbilisi State Medical University
🇬🇪Tbilisi, Georgia
Department of radiation oncology, University Hospital Essen
🇩🇪Essen, Germany
Agioi Anargiroi General Oncology Hospital of Kifissia
🇬🇷Athens, Greece
Theagenio Anticancer Hospital
🇬🇷Thessaloníki, Greece
IRCCS AOU San Martino
🇮🇹Genova, Italy
Istituto Oncologico Veneto Irccs
🇮🇹Padova, Italy
Tokyo Medical University Hospital
🇯🇵Tokyo, Japan
Sheba Medical Center
🇮🇱Ramat Gan, Israel
University Medical Center Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Germany
Strahlenklinik des Uni-Klinikums
🇩🇪Erlangen, Germany
Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika
🇭🇺Szeged, Hungary
Centro di Riferimento Oncologico
🇮🇹Aviano, Italy
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia
🇮🇹Brescia, Italy
Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie
🇩🇪Essen, Germany
Rabin Medical Center
🇮🇱Petach Tiqva, Israel
Universitaetsmedizin Rostock
🇩🇪Rostock, Germany
Osaka International Cancer Institute
🇯🇵Osaka, Japan
Orszagos Onkologiai Intezet Sugarterapias Osztaly
🇭🇺Budapest, Hungary
Az. USL 6 Ospedali Riuniti-Ospedale di Livorno
🇮🇹Livorno, Italy
National Cancer Center
🇰🇷Goyang-si, Korea, Republic of
National Cancer Center Hospital East
🇯🇵Chiba, Japan
Rambam Healthcare Campus
🇮🇱Haifa, Israel
Ospedale "Vito Fazzi" Lecce
🇮🇹Lecce, Italy
AOU "Luigi Vanvitelli"
🇮🇹Napoli, Italy
Policlinico di Modena
🇮🇹Modena, Italy
AORN Ospedale dei Monaldi
🇮🇹Napoli, Italy
National Cancer Center Hospital
🇯🇵Chuo-ku Tokyo, Japan
Fundacio Althaia
🇪🇸Manresa, Spain
Hospital 12 de Octubre
🇪🇸Madrid, Spain
Clatterbridge Cancer Centre NHS Foundation Trust
🇬🇧Wirral, United Kingdom
Regents of the University of California
🇺🇸San Francisco, California, United States
UCSF
🇺🇸San Francisco, California, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
University of Cincinnati Medical Center
🇺🇸Cincinnati, Ohio, United States
University of Oklahoma Health Sciences Center- Stephenson Cancer Center
🇺🇸Oklahoma City, Oklahoma, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
MD Anderson
🇺🇸Houston, Texas, United States
IHO Corporation/Utah Cancer Specialists
🇺🇸Salt Lake City, Utah, United States
Azienda Ospedaliero-Universitaria Careggi
🇮🇹Firenze, Italy
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
🇮🇹Meldola, Italy
Istituto Nazionale dei Tumori
🇮🇹Milan, Italy
Azienda Ospedaliero Universitaria di Parma
🇮🇹Parma, Italy
Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela
🇧🇷Barretos, Brazil
Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro
🇧🇷Natal, Brazil
Centro Gaúcho Integrado, Rua Costa
🇧🇷Porto Alegre, Brazil
Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer
🇧🇷Porto Alegre, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC
🇧🇷Santo André, Brazil
Oswaldo Cruz German Hospital
🇧🇷São Paulo, Brazil
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kamigyo-ku, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama, Japan
Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie
🇩🇪Leipzig, Germany
Hospital Civil (Hospital Regional Universitario)
🇪🇸Málaga, Spain
University Hospital hradec Kralové
🇨🇿Hradec Králové, Czechia
Princess Alexandra Hospital, Cancer Trials Unit
🇦🇺Woolloongabba, Australia
Clinica Universitaria Reina Fabiola
🇦🇷Cordoba, Argentina
Instituto de Oncologia de Rosario
🇦🇷Santa Fe, Argentina
Ohio State University
🇺🇸Columbus, Ohio, United States
The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC)
🇺🇸Birmingham, Alabama, United States
Banner MD Anderson Cancer Center
🇺🇸Gilbert, Arizona, United States
UC San Diego Moores Cancer Center
🇺🇸La Jolla, California, United States
The Oncology Institute of Hope & Innovation
🇺🇸Whittier, California, United States
Yale Cancer Center
🇺🇸New Haven, Connecticut, United States
ASCLEPES Research Centers
🇺🇸Weeki Wachee, Florida, United States
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
IACT Health, John B. Amos Cancer Center
🇺🇸Columbus, Georgia, United States
Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center
🇺🇸Boston, Massachusetts, United States
Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus
🇺🇸Louisville, Kentucky, United States
Ashland-Bellefonte Cancer Center
🇺🇸Ashland, Kentucky, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
MidAmerica Cancer Care
🇺🇸Kansas City, Missouri, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
NYU Langone Hospital-Long Island Oncology
🇺🇸Mineola, New York, United States
Comprehensive Cancer Center of Nevada (Southern Hills) (USA)
🇺🇸Las Vegas, Nevada, United States
Wake Forest University School of Medicine
🇺🇸Winston-Salem, North Carolina, United States
Clinica Viedma
🇦🇷Viedma, Argentina
Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima
🇧🇷São José Do Rio Preto, Brazil
Instituto do Cancer do Estado de Sao Paulo (ICESP)
🇧🇷São Paulo, Brazil
CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont
🇨🇦Montreal, Canada
Hopital Maisonneuve-Rosemont
🇨🇦Montreal, Canada
CHU de Quebec-Université Laval
🇨🇦Québec, Canada
Beijing Cancer Hospital
🇨🇳Beijing, China
Hokkaido University Hospital
🇯🇵Kita-Ku, Japan
Sunnybrook Research Institute
🇨🇦Toronto, Canada
Hunan Cancer Hospital
🇨🇳Changsha, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
The 5th Affiliated Hospital of Sun yet-sen university
🇨🇳Guangdong, China
The 2nd Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, China
Shantou University Cancer Hospital
🇨🇳Shantou, China
Liaoning Cancer Hospital & institute
🇨🇳Shenyang, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjin, China
Henan Cancer Hospital
🇨🇳Zhengzhou, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, China
Tongji Hospital/Tongji Medical College, Huazhong University of Science
🇨🇳Wuhan, China
CHU Amiens Picardie - Hopital Sud
🇫🇷Amiens, France
Fakultni Nemocnice Ostrava
🇨🇿Ostrava-Poruba, Czechia
KOC KNTB a.s. Zlín
🇨🇿Zlín, Czechia
Institut de Cancérologie de l Ouest (ICO)
🇫🇷Angers, France
CHRU de Brest Hopital Morvan
🇫🇷Brest, France
CHU de Grenoble
🇫🇷Grenoble Cedex 9, France
Centre Guillaume Le Conquerant
🇫🇷le Havre, France
Clinique Victor Hugo
🇫🇷Le Mans, France
Centre hospitalier Libourne
🇫🇷Libourne, France
Hôpital du Scorff
🇫🇷Lorient, France
Service d'Oncologie Médicale, CHU Timone
🇫🇷Marseille, France
Centre Leon Berard
🇫🇷Lyon, France
Hôpital Nord Franche Comté
🇫🇷Montbeliard, France
Institut Regional du Cancer de Montpellier
🇫🇷Montpellier, France
CHU Nimes
🇫🇷Nimes, France
LHopital prive du Confluent Nantes
🇫🇷Nantes Cedex 2, France
CCConcorde (GCS)
🇫🇷Neuilly sur Seine, France
Institut Curie
🇫🇷Paris, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Institut de Cancérologie de l'Ouest - Site Saint Herblain
🇫🇷Saint Herblain, France
Centre Eugène Marquis
🇫🇷Rennes Cedex, France
Centre Henri Becquerel CLCC
🇫🇷Rouen Cedex, France
CHP Saint Gregoire FINESS
🇫🇷Saint Gregoire, France
Institut Claudius Regaud - IUCT-O
🇫🇷Toulouse, France
ICANS
🇫🇷Strasbourg, France
CHU de Tours
🇫🇷Tours, France
Cancer Research Cent 4
🇬🇪Tbilisi, Georgia
IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO
🇮🇹Milan, Italy
ASL2_Presidio Ospedaliero San Paolo
🇮🇹Savona, Italy
Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale"
🇮🇹Napoli, Italy
Fondazione Policlinico Universitario Agostino Gemelli
🇮🇹Rome, Italy
Hyogo Cancer Center
🇯🇵Hyogo, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka, Japan
Tokai University Hospital
🇯🇵Kanagawa, Japan
Okayama University Hospital
🇯🇵Kita-ku, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Cancer Institute Hospital of JFCR
🇯🇵Koto-ku, Japan
Shizuoka Cancer Center
🇯🇵Nagaizumi-cho, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
National Cancer Center Hematologic Oncology
🇰🇷Goyang-si, Korea, Republic of
Asan Medical Center, Asian Cacer Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
KonKuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii
🇵🇱Gdańsk, Poland
Seoul National University Boramae Medical Center
🇰🇷Seoul, Korea, Republic of
Pusan National University Yangsan Hospital, Oncol & Hematology
🇰🇷Yangsan, Korea, Republic of
Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach
🇵🇱Gliwice, Poland
NZOZ Provita Prolife Centrum Medyczne
🇵🇱Łódź, Poland
SP ZOZ MSWiA z W-M CO w Olsztynie
🇵🇱Olsztyn, Poland
Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT)
🇵🇹Faro, Portugal
Hospital de Braga
🇵🇹Braga, Portugal
Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E
🇵🇹Porto, Portugal
Hospital Pedro Hispano
🇵🇹Porto, Portugal
Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky
🇷🇺Krasnoyarsk, Russian Federation
Kursk Regional Clinical Oncology Dispensary
🇷🇺Kursk, Russian Federation
EuroCityClinic
🇷🇺Saint Petersburg, Russian Federation
FGBU N.N.Blokhin Russian Cancer Research Center
🇷🇺Moscow, Russian Federation
Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology)
🇷🇺Saint Petersburg, Russian Federation
Republican Clinical Oncological Dispensary of Bashkortostan
🇷🇺Ufa, Russian Federation
State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS)
🇷🇺Ufa, Russian Federation
Hospital Clinic Barcelona
🇪🇸Barcelona, Spain
FSBI National Med Research Cancer Center N.N. Petrov
🇷🇺Saint-Petersburg, Russian Federation
State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital
🇷🇺Yaroslavl, Russian Federation
Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro"
🇪🇸A Coruña, Galicia, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro
🇪🇸A Coruna, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Institut Català d'Oncologia Badalona
🇪🇸Barcelona, Spain
Institut Català d'Oncologia, Hospital Duran
🇪🇸Barcelona, Spain
Institut Català d'Oncologia
🇪🇸Girona, Spain
Institut Universitari Dexeus-Quiron (ESP)
🇪🇸Barcelona, Spain
Clinica Universidad de Navarra
🇪🇸Pamplona, Spain
Hospital Reina Sofía
🇪🇸Cordoba, Spain
Hospital Universitario Insular de Gran Canaria
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Ramon y Cajal
🇪🇸Madrid, Spain
Althaia, Xarxa Assistencial
🇪🇸Manresa, Spain
Hospital Universitario Marqués de Valdecilla. Santander
🇪🇸Santander, Spain
Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP)
🇪🇸Valencia, Spain
IVO
🇪🇸Valencia, Spain
Hospital Universitario La Fe
🇪🇸Valencia, Spain
Aberdeen Royal infirmary, Dept. of Oncology
🇬🇧Aberdeen, United Kingdom
NHS Greater Glasgow and Clyde
🇬🇧Glasgow, United Kingdom
Royal Marsden NHS Foundation Trust
🇬🇧Chelsea, United Kingdom
Royal Surrey County Hospital
🇬🇧Guildford, United Kingdom
The Royal Marsden NHS Foundation Trust - Sutton
🇬🇧Sutton, United Kingdom
University Hospital Southampton NHS Foundation Trust
🇬🇧Southampton, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Mount Vernon Cancer Centre
🇬🇧Northwood, United Kingdom
Nottingham University Hospitals NHS Trust
🇬🇧Nottingham, United Kingdom
Karmanos Cancer institute
🇺🇸Detroit, Michigan, United States
University of Missouri - Ellis Fischel Cancer Center
🇺🇸Columbia, Missouri, United States
University of Virginia Medical Center
🇺🇸Charlottesville, Virginia, United States
National Cancer Institute
🇧🇷Rio De Janeiro, Brazil
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
Centre hospitalier Universitaire de Bordeaux
🇫🇷Bordeaux, France
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
Hospital Na Bulovce
🇨🇿Prague, Czechia
Institut Sainte Catherine
🇫🇷Avignon Cedex 9, France
The Public Hospital L'Institut de Cancerologie de Lorraine
🇫🇷Vandoeuvre les Nancy, France
Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie
🇩🇪Mannheim, Germany
State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan"
🇷🇺Kazan, Russian Federation
Szpitale Pomorskie Sp. z o.o.
🇵🇱Gdynia, Poland
Kiev City Clinical Oncology Centre
🇺🇦Kiev, Ukraine
Medical center ASKLEPION LLC
🇺🇦Khodosivka, Ukraine
Cliniques universitaires Saint-Luc
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Gent UZ Gent
🇧🇪Gent, Belgium
Charing Cross Hospital
🇬🇧London, United Kingdom
University of Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
NYU Grossman School of Medicine
🇺🇸New York, New York, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
🇺🇸New York, New York, United States
Fujian Cancer Hospital
🇨🇳Fuzhou, China