What is the minimum amount of folic acid that improves blood vessel function in children with type 1 diabetes?

Phase 4

Completed

• Conditions: Type 1 diabetes; Endothelial dysfunction; Metabolic and Endocrine - Diabetes; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12610000176066
• Lead Sponsor: Dr Alexia Pena

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-02-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Type 1 diabetes of longer than 1 year duration (attending the Diabetes clinic at Women's and Children's Hospital, Adelaide)

Exclusion Criteria

History of smoking or serum cotinine level >28 nmol/l;
Coeliac disease, screened by transglutaminase immunoglobulin A (IgA);
Treatment with statins or angiotensin converting enzyme inhibitors;
Vitamin supplementation;
Vitamin B12 deficiency;
Intercurrent illness or ketosis at the time of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in endothelial function measured by flow mediated dilatation (FMD)[2 hours after folic acid in one of the three available doses or placebo, in random order, at 4 visits 4 weeks apart]

Secondary Outcome Measures

Name	Time	Method
il[Nil]