An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients
- Conditions
- Cardiac Surgery
- Interventions
- Other: IV fluid according to PPVOther: fluids according to standard care
- Registration Number
- NCT01681758
- Lead Sponsor
- Austin Health
- Brief Summary
We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery
- Detailed Description
1. The investigators will study patients after cardiac surgery
2. The investigators will collect data on standard care in pre-intervention population
3. The investigators will collect demographic and clinical data
4. The investigators will collect biochemical data in the first 24 hours after surgery
5. The investigators will collect biochemical, physiological and clinical outcome data
6. The investigators will compare the standard care and intervention period data
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 104
- immediately after ICU admission after cardiac surgery
- mandatory mechanical ventilation -
- Pressure support ventilation
- ECMO
- Intra-aortic balloon counterpulsation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description PPV IV fluid according to PPV use PPV to guide fluid therapy standard care fluids according to standard care fluids according to standard care
- Primary Outcome Measures
Name Time Method Mean amount of fluid given in the first 24 hours after surgery 24 hours all intravenous fluid administered
- Secondary Outcome Measures
Name Time Method Physiological outcome 24 hours Blood lactate
Trial Locations
- Locations (1)
Austin Hospital
🇦🇺Melbourne, Victoria, Australia