An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

Phase 2

Completed

• Conditions: Cardiac Surgery

• Registration Number: NCT01681758
• Lead Sponsor: Austin Health

Brief Summary

We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery

Detailed Description

1. The investigators will study patients after cardiac surgery

2. The investigators will collect data on standard care in pre-intervention population

3. The investigators will collect demographic and clinical data

4. The investigators will collect biochemical data in the first 24 hours after surgery

5. The investigators will collect biochemical, physiological and clinical outcome data

6. The investigators will compare the standard care and intervention period data

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-09-06
• Study First Submitted QC: 2012-09-07
• Study First Posted: 2012-09-10
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-09
• Last Update Posted: 2013-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

1. immediately after ICU admission after cardiac surgery
2. mandatory mechanical ventilation -

Exclusion Criteria

1. Pressure support ventilation
2. ECMO
3. Intra-aortic balloon counterpulsation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Mean amount of fluid given in the first 24 hours after surgery	24 hours	all intravenous fluid administered

Secondary Outcome Measures

Name	Time	Method
Physiological outcome	24 hours	Blood lactate

Trial Locations

Locations (1)

Austin Hospital; 🇦🇺 Melbourne, Victoria, Australia