Relationship between serum level of vitamin-D3 and Expanded Disability Status Scale (EDSS) changes before and 8 weeks after methylprednisolone pulse therapy in multiple sclerosis (MS) patients
Phase 2
- Conditions
- Multiple Sclerosis.Disseminated Multiple Sclerosis
- Registration Number
- IRCT201305281859N7
- Lead Sponsor
- Vice chancellor for research ,Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1- Patients with multiple sclerosis based on McDonalds Criteria. 2- Patients type relapsing-remitting (RRMS). 3-EDSS less than 5 before attack. 4-Less than 5 years after MS diagnosis. 5-Less than 5 attacks in the duration of MS diagnosis.
Exclusion criteria:
1- Association with any diseases such as liver diseases, renal diseases, bone marrow disfunction, sarcoidosis, renal stone,hypercalcemia. 2-pregnancy or breast feeding. 3-Using drugs such as hydrochlorothiazide, phenytoin, barbiturate, digital.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The rate of recovery after attack. Timepoint: Before intervention and two months after intervention. Method of measurement: Physical examination done by neurologist and using Expanded Disability Status Scale (EDSS).
- Secondary Outcome Measures
Name Time Method Expanded Disability Status Scale (EDSS). Timepoint: Before intervention and two months after intervention. Method of measurement: Physical examination done by neurologist based on revised Mc-Donald (2010).;Serum level of 25-hydroxy vitamin-D3. Timepoint: Before intervention and two months after intervention. Method of measurement: Blood test.