Desensitization to wheat
Not Applicable
- Conditions
- Wheat Allergy, Anaphylaxis, Food Allergy.Anaphylactic reaction due to foodT78.0
- Registration Number
- IRCT20181220042066N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Age more than 5 years
A positive history of severe wheat allergy (Anaphylaxis)
A positive specific IgE to wheat (in vivo or in vitro tests)
Confirmation of wheat allergy by a oral food challenge (OFC)
Exclusion Criteria
Dissatisfaction of patients or their parents to perform OFC
Viral or bacterial infectious diseases
Unstable or uncontrolled asthma in the time of OFC
Use of medications in the time of skin prick test (SPT) or DBPCFC
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1- Evaluation of desensitization to wheat. Timepoint: Evaluation of desensitization to wheat after 12 months after Immunotherapy. Method of measurement: 1- Skin Prick Test,2- Specific IgE measurement, 3-clinical symptoms and oral food challenge.;2-Evaluation of tolerance to wheat. Timepoint: Evaluation of tolerance to wheat after use of free wheat products for two weeks. Method of measurement: clinical symptoms and oral food challenge.
- Secondary Outcome Measures
Name Time Method Percentage of T regulatory cells. Timepoint: Before and after Immunotherapy. Method of measurement: Flowcytometry.;Wheal and flare in Skin Prick Test. Timepoint: Before and after Immunotherapy. Method of measurement: observation of wheal and flare.;Specific IgE level to wheat. Timepoint: Before and after Immunotherapy. Method of measurement: Immunoblotting test Allergy screen.;Complications. Timepoint: Before and after Immunotherapy. Method of measurement: examination and observation of clinical symptoms.