Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

Not Applicable

Recruiting

• Conditions: Time; Stress Response; Intubation; Dexmedetomidine; Laryngoscopy
• Interventions: Drug: Dexmedetomidine; Drug: Saline

• Registration Number: NCT07165483
• Lead Sponsor: Tanta University

Brief Summary

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

Detailed Description

Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.

Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-03
• Study First Submitted QC: 2025-09-03
• Study First Posted: 2025-09-10
• Study Start: 2025-09-11
• Last Update Submitted: 2025-09-11
• Last Update Posted: 2025-09-12
• Primary Completion: 2026-03-01
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.

Exclusion Criteria

• Severe cardiovascular problems.
• Respiratory disorders.
• Diabetes.
• Hypertension.
• Obesity.
• Allergic reaction to study drugs.
• Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
• Medications that affect heart rate (HR) or blood pressure (BP).
• Pregnant.
• Currently breast-feeding women.
• History of sleep apnea.
• Those for emergency procedures.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group D20	Dexmedetomidine	Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.
Group D10	Dexmedetomidine	Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.
Group C	Saline	Patients will receive saline before induction of anesthesia as a control group.

Primary Outcome Measures

Name	Time	Method
Mean arterial pressure	Till the end of the surgery (Up to 2 hours)	Mean arterial pressure will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.

Secondary Outcome Measures

Name	Time	Method
Need for intraoperative fentanyl	Intraoperatively	Need for intraoperative fentanyl will be recorded.
Heart rate	Till the end of the surgery (Up to 2 hours)	Heart rate will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.
Incidence of adverse events	24 hours postoperatively	Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, or any other complication.

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, El-Gharbia, Egypt