Chronic Cerebrovascular Disease Oriented Biobank Consortium Operatio

Not Applicable

Recruiting

Conditions: Diseases of the nervous system

Registration Number: KCT0003391

Lead Sponsor: Ajou University Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 945

Inclusion Criteria

? Person aged 40 years or below 90 years based on registration time (Baseline, B-1)
Do not calculate the age of the U.S., and both the age of resident registration and actual age are over 40 years old.
? person who can have sufficient hearing and vision to perform a neuropsychiasis test
However, even corrected hearing and vision may participate if the performance of the neuro-psychoactic examination is not impaired
? Person who have no medical condition in brain imaging (MRI, PET) examinations that can participate in neuroimaging studies - person without an artificial heart monitor, an aneurysm clip, an artificial heart valve, or an ear transplant
? Person who has agreed to participate in the research including collection of blood, treatment and survey
A person who can be accompanied by the same guardian at all times during the study period, and is recommended to have the same guardian come at each progress trace
The caregiver is aware of the condition of the patient before the occurrence except the caregiver, and is able to observe the occurrence of the patient for two hours or more a day.
? person whose medical history is stable without increasing the amount of medication within three months of participation. However, some changes in the treatment guidelines may be accepted based on the judgment of the researchers.

Exclusion Criteria

? If the subjects of all target groups are diagnosed with neurological diseases and vascular dementia, they can not participate in this research.
A. Other vascular dementia such as multi-infarch disease and strategic infarction dementia due to multiple cerebral infarction
B. Brain lesions with neuropathy
ex) Huntington's disease, Normal pressure hydrocepalus, Brain tumor, Progressive supranuclear palsy
C. Spastic diseases that can cause large releases (GTCS)
D. Brain diseases that can cause secondary dementia, such as carbon monoxide poisoning or alcoholic dementia.
? Person with evidence of infection, infarction, and other local lesions in brain MRI conducted during Screening or Baseline.
However, MRI performed during Screening could participate if there were less than 5 lacune multiple heat sources.
? Person with major mental disorders, such as schizophrenia, major depression, and bipolar disorder, described by DSM-III within the past two years.
? Person with an unadjusted sleep disorder, anxiety or behavioral disorder within three months of the screening time.
? At the time of screening, who has a history of abuse or dependence on alcohol or drugs within the past two years.
? Person who is deemed difficult to comply with the research results due to the following diseases :
A. Person diagnosed with malignant tumor within 3 years of the screening time. However, it excludes cancer that can be detected and treated in the early stages and determines if it is a mild case based on the judgment of the researchers. If you have been diagnosed with cancer, but have been completely cured at this point, you can register
B. A medical condition that can cause mental abnormalities - those who have thyroid, liver or kidney disease.
Evaluation of a subject's disease is based on the medical judgment of the researchers
? Except in cases where drug use, such as antidepressants, antipsychotics, antianxiety drugs, or sedation sleep pills, can interfere with neuropsychological evaluation
A person who is likely to be pregnant or breast-feed May participate after more than two years of menopause or infertility
? Who is participating in other drug research. However, those who participate in observational studies without medication may participate in this study
If PET scan can not be performed. Includes but is not limited to (pastrophobia, not limited to)If there is or is suspected to be an overresponsiveness of 18 F-flutemetamol or its subtants (e.g. polysorbate 80).

Study & Design

Study Type: Observational Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CDR(Clinical Dementia Rating), CDR-SOB(Clinical Dementia Rating-Sum of Box);GDS(Global Deterioration Scale);MMSE(Mini-Mental Status Examination);Diagnosis

Secondary Outcome Measures

Name	Time	Method
Biological specimens(Plasma, Serum, DNA, human skin fibroblast);Neuroimaging resources(amyloid PET, MRI);Lifelog data;Neuropsychological function(attention, language, visuospatial, memory, frontal lobe function);GWAS(Genome-Wide Association Study) data