Older Adult Training Study With Creatine and CLA
- Conditions
- Sarcopenia
- Registration Number
- NCT00473902
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Brief Summary
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (\> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise
- Detailed Description
Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
- Healthy,
- Ambulatory,
- Recreationally active,
- Community dwelling
- Evidence of coronary heart disease;
- Congestive heart disease;
- Uncontrolled hypertension;
- Chronic obstructive pulmonary disease;
- Diabetes mellitus;
- Renal failure;
- Major orthopedic disability; and
- Smoking
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption) six months
- Secondary Outcome Measures
Name Time Method a. Functional capacity b. Strength with weight machines six months
Trial Locations
- Locations (1)
McMaster University Medical Center
🇨🇦Hamilton, Ontario, Canada