Zurich Coronavirus Cohort: an observational study to determine long-term clinical outcomes and immune responses after coronavirus infection (COVID-19), assess the influence of virus genetics, and examine the spread of the coronavirus in the population of the Canton of Zurich, Switzerland

Not Applicable

Conditions: COVID-19 (SARS-CoV-2 infection)
Infections and Infestations

Registration Number: ISRCTN14990068

Lead Sponsor: niversity of Zurich

Brief Summary: Preprint results in https://doi.org/10.1101/2020.12.21.20248619 non-peer-reviewed results of efficacy of a proximity tracing app in preprint (added 17/03/2021) 2021 Preprint results in https://doi.org/10.1101/2021.02.27.21252572 non-peer-reviewed results on long-term disease burden in preprint (added 17/03/2021) 2021 Preprint results in https://doi.org/10.1101/2021.12.15.21267776 Immunological analyses (added 08/07/2022) 2022 Preprint results in https://doi.org/10.1101/2022.06.22.22276746 Natural course of post-COVID syndrome (added 08/07/2022) 2022 Results article in https://doi.org/10.2196/35653 Analysis of exposure notification cascade in the SwissCovid digital proximity tracing app (added 08/07/2022) 2021 Results article in https://doi.org/10.1371/journal.pone.0254523 Burden of post-COVID syndrome (added 08/07/2022) 2021 Results article in https://doi.org/10.3389/ijph.2021.1603992 Effectiveness of digital proximity tracing app (added 08/07/2022) 2022 Results article in https://doi.org/10.1371/journal.pone.0264655 Mental health of COVID-infected people during isolation (added 08/07/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35982045/ Heterogenous humoral and cellular immune responses (added 14/05/2024) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37257891/ Recovery at 2 years (added 14/05/2024) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37366496/ Work ability and occupational changes (added 14/05/2024)

Detailed Description: Not available

Recruitment & Eligibility

Status: Ongoing

Sex: All

Target Recruitment: 3200

Inclusion Criteria

Current participant inclusion criteria as of 08/07/2022:
Index cases:
1. Individuals newly diagnosed with SARS-CoV-2 infection in the Canton of Zurich from the start of the study (prospective index cases)
2. Individuals previously diagnosed with SARS-CoV-2 infection in the Canton of Zurich between February 2020 and the start of the study (retrospective index cases)

Close contacts:
1. Symptomatic and asymptomatic close contacts of prospective index cases as identified by routine contact tracing by the Department of Health of the Canton of Zurich
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Previous participant inclusion criteria:
Index cases:
1. Individuals newly diagnosed with SARS-CoV-2 infection in the Canton of Zurich from the start of the study (prospective index cases)
2. Individuals previously diagnosed with SARS-CoV-2 infection in the Canton of Zurich between February 2020 and the start of the study (retrospective index cases)

Close contacts:
1. Symptomatic and asymptomatic close contacts of prospective index cases as identified by routine contact tracing by the Health Directorate of the Canton of Zurich

Exclusion Criteria

1. Children and adolescents aged <18 years
2. Insufficient knowledge of the German language
3. Individuals with primary residence outside of the Canton of Zurich, Switzerland
4. Individuals that are unable to follow study procedures
5. Individuals that cannot be reached on maximum of 5 attempts
6. Individuals that do not provide informed consent