A randomized comparative study of effect of preoperative nebulization with ketamine versus magnesium sulphate on incidence of postoperative sore throat in patient undergoing surgery in general anaesthesia with endotracheal intubation.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- To evaluate and compare effect on hemodynamics of the patient after magnesium sulphate and ketamine nebulization and normal saline nebulization.
研究概览
简要总结
Comparison of effect of preoperative nebulization with Ketamine versus Magnesium Sulphate on incidence of postoperative sore throat in patient undergoing surgery in general anaesthesia with endotracheal intubation.
Purpose of trial is to compare the incidence of sore throat at 0hours, 2hours, 6 hours, 8hours, 12hours, 24hours.
Hemodynamic parameters are compared.
Preoperative nebulization will be done for 10mins with ultrasonic/mesh nebuliser machine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 58.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status 1-2 Supine position under General Anaesthesia Informed Consent.
排除标准
- •Patients with Physical Status of ASA Grade 3 or greater Preoperative sore throat Upper airway infection Duration of surgery >120 mins Oral surgeries Pregnant women Severe cardiorespiratory, hepatic, renal, neurological or endocrinal disease Patients with known hypersenstivity or drug allergies Obese patients weight >80kg Epileptic patient Nausea, retching or vomiting within 48hr before surgery History of motion sickness Patients who refuse to participate in the study.
结局指标
主要结局
To evaluate and compare effect on hemodynamics of the patient after magnesium sulphate and ketamine nebulization and normal saline nebulization.
时间窗: 0 hour, 2 hours, 6 hours, 8 hours, 12hours, 24hours
To evaluate and compare the incidence of postoperative sore throat after magnesium sulphate and ketamine nebulization and normal saline nebulization.
时间窗: 0 hour, 2 hours, 6 hours, 8 hours, 12hours, 24hours
次要结局
- To evaluate side effect (if any) of ketamine and magnesium sulphate.(To evaluate patients satisfaction with nebulization done by ketamine and magnesium sulphate.)