Comparison of Two Programs for Weight Loss and Impact on Metabolic Syndrome

Not Applicable

Completed

Conditions: Metabolic Syndrome

Interventions: Behavioral: Emotional brain training
Behavioral: Behavioral weight loss

Registration Number: NCT02023515

Lead Sponsor: Kelly Webber

Brief Summary: The purpose of this study is to learn the impact stress may have on weight management and emotional eating.

Detailed Description: The investigator's long-term goal is to contribute to the development of empirically-based, clinically-useful weight loss and weight maintenance interventions. The objective in this application is to obtain proof of feasibility for a weight loss and maintenance intervention that addresses the underlying issue of stress, as an effective approach to long-term weight loss and maintenance. The central hypothesis for this application is that the weight management intervention utilizing stress management skills will produce weight loss and significant improvements in stress and metabolic syndrome biomarkers at 10 and 20 weeks follow-up. This hypothesis was formulated based upon data showing that stress is associated with increased risk of obesity and a few small studies that have shown this method of stress management can produce long-term weight loss and maintenance and decreased depression and stress. The rationale for the proposed studies is that proof of feasibility for such an intervention will enable subsequent definitive studies at the R01 level. If, however, the investigators were to unexpectedly disprove the concept, such a result would also be valuable because it would lead the investigators to shift focus and redistribute resources accordingly. To test the central hypothesis, and thereby accomplish the objective for this application, the following specific aims will be pursued:

1. Compare a stress management based program to a standard behavioral weight loss program for weight loss and cost-effectiveness. The approach will involve two different intervention groups. Group 1(control) will receive a standard behavioral weight loss program. Group 2 will receive a stress management based intervention built on research in neuroscience and principles of the attachment theory.

2. Determine secondary outcomes from both interventions, including stress as measured by the perceived stress scale. It is hypothesized that Group 2 will show greater improvements in stress at both 10 and 20 weeks follow-up than Group 1.

At the completion of this study, the investigators expect to determine the type of intervention that produces the greatest weight loss in a community sample at 10 and 20 weeks follow-up. The investigators will also have determined what impact the two interventions have on secondary outcomes, including stress as measured by salivary cortisol and telomere length; depression, disordered eating patterns, dietary intake, and physical activity.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 49

Inclusion Criteria

be 25-55 years of age
have a BMI of > 28 and <45
meet criteria for at least one additional risk factor for metabolic syndrome (Participants will be screened for waist circumference and blood pressure to ensure inclusion in the study.)
own and use a smart phone.

Exclusion Criteria

have a medical diagnosis of orthopedic or joint problems that may prohibit regular exercise
endorse any of the first three items on the Physical Activity Readiness Questionnaire (PAR-Q): heart problems, chest pain, faintness or dizzy spells
endorse any of the other items on the PAR-Q without a physician's consent
have had a hospitalization for a psychiatric disorder within the last year
have a history of anorexia or bulimia nervosa
have a medical diagnosis of cancer or HIV
have a diagnosis of a major psychiatric disorder (i.e. bipolar disorder or schizophrenia) or taking anti-psychotic medications
be pregnant, nursing, or planning to become pregnant within the study period
be less than 9 months post-partum
have a weight loss of > 10 pounds in the last six months
be on more than two medications for hypertension control
greater than stage 3 kidney disease
be taking insulin to control diabetes
be taking Coumadin
be taking Lasix
anyone, who in the opinion of the study investigators, would not be a good candidate for the study

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Stress Management	Emotional brain training	Approximately half of the participants will be randomized to a stress management arm. Participants will undergo Emotional Brain Training during a 90 minute session once per week for ten weeks in order to rewire the brain and improve stress management techniques.
standard behavioral weight loss	Behavioral weight loss	Half of participants will receive a standard behavioral weight loss program in 90 minute sessions once per week for 10 weeks

Primary Outcome Measures

Name	Time	Method
Weight Loss	Weight change from baseline to 20 weeks	Weight change from baseline to 20 weeks

Secondary Outcome Measures

Name	Time	Method
Decrease in Stress	PSS change from baseline to 20 weeks	Stress was measured by the Perceived Stress Scale (PSS). This scale measures stress on a scale of 0 to 40 points. The results are reported as a total score on the scale. Higher numbers indicate more stress than lower numbers.