ess inspiration- expiration during operation in the belly in patients with infection in the belly

Not Applicable

Conditions: Health Condition 1: null- Adult patients with intraabdominal infection undergoing laparotomy

Registration Number: CTRI/2017/12/010732

Lead Sponsor: Dr Dalim Kumar Baidya

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Age between 18 and 70 years

Emergency laparotomy expected duration >2 hours and < 5 hours

Peritonitis (suspected or identified abdominal source of infection) of less than 5 days duration

Preoperative risk index for pulmonary complications >2

Exclusion Criteria

1. Mechanical ventilation within 2 weeks preceding surgery

2. BMI >= 35, < 18

3. History of respiratory failure or sepsis within the 2 weeks preceding surgery

4. Requirement for intrathoracic surgery, history of lung surgery

5. History of smoking or COPD, with (non-invasive) ventilation and/or oxygen therapy at home and/or repeated systemic corticosteroid therapy for acute exacerbations of COPD

6. Progressive neuromuscular illness

7. ALI or acute respiratory distress syndrome expected to require prolonged post-operative mechanical ventilation,

8. Persistent hemodynamic instability or intractable shock

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulmonary complications occurring up to day 7 after surgery <br/ ><br> <br/ ><br>1. Acute respiratory failure <br/ ><br> <br/ ><br>Mild respiratory failure responding to supplemental oxygen <br/ ><br> <br/ ><br>Severe respiratory failure requiring invasive or noninvasive mechanichal ventilation <br/ ><br> <br/ ><br>2. Pneumonia <br/ ><br> <br/ ><br>3. ARDS <br/ ><br> <br/ ><br>4. PneumothoraxTimepoint: Pulmonary complications occurring up to day 7 after surgery <br/ ><br> <br/ ><br>1. Acute respiratory failure <br/ ><br> <br/ ><br>Mild respiratory failure responding to supplemental oxygen <br/ ><br> <br/ ><br>Severe respiratory failure requiring invasive or noninvasive mechanichal ventilation <br/ ><br> <br/ ><br>2. Pneumonia <br/ ><br> <br/ ><br>3. ARDS <br/ ><br> <br/ ><br>4. Pneumothorax

Secondary Outcome Measures

Name	Time	Method
1. Pulmonary complications graded on a scale 0 to 410 <br/ ><br> <br/ ><br>2. Ventilation related adverse events during surgery <br/ ><br> <br/ ><br>3. Severe sepsis, septic shock, organ dysfunction <br/ ><br> <br/ ><br>4. Number of days of ICU admission and duration of hospital stay <br/ ><br> <br/ ><br>5. Surgical complications <br/ ><br> <br/ ><br>6. Pre and postoperative serum IL 6, IL 8, and TNFÎ± â?? first sample will be obtained at the beginning of surgery and second sample will be obtained at 24 hoursTimepoint: Till the discharge