Comparison of Intraoperative lung protective ventilation with conventional ventilation on postoperative pulmonary complications in CABG
- Conditions
- postoperation complications of respiratory system.Postprocedural respiratory disorder, unspecified
- Registration Number
- IRCT2015040115774N3
- Lead Sponsor
- Vice chancellor for research, Iran university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
Inclusion criteria are patients candidate for CABG operation under general anesthesia; Patient's satisfaction with participating in the study and doing the respiratory examinations; BMI< 30 kg/m² age more than 18 and under 70; No pregnancy; No emergent surgery; No previous respiratory system surgery; No history of chronic obstructive pulmonary disease; No sleep disorder; No History of immune suppressant therapy( chemotherapy or radiotherapy) in the last 2 months; No acute respiratory damage or acute respiratory distress syndrome; No repeated treatment with systemic corticosteroid; No liver or neuromuscular disorders; No alcohol or substance abuse; No anesthetic drugs allergy; No cigarette smoking (less than 10 pack/year).
Exclusion criteria are Hemoglobin < 10; Albumin <3 g/dl; Continuous hemodynamic unstability; Resistant shock; Prediction of long term mechanical ventilation after the surgery; non-early extubation (more than 6 hours after end of the surgery).
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative pulmonary complications. Timepoint: after the surgery. Method of measurement: 3 or more of these six postoperative pulmonary complications: cough, discharge increase, dyspnea, chest pain, temperature more than 38C, heart rate >100 per minute.
- Secondary Outcome Measures
Name Time Method Modified Clinical Pulmonary Infection Score. Timepoint: After the surgery. Method of measurement: According to mentioned parameteres : Glasco scale, Mean Arterial Pressure, need for vasopressor to support cardiovascular system,Serum Aspartate Transaminase Level, Liver bilirubin, Protrombin time and platlets, coagulation factors and serum creatine.;IL-6 levels. Timepoint: before, exactly after and also after 24 hours of the surgery. Method of measurement: laboratory.