Effect of a 12-week cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Dong-A University Hospital0 个研究点目标入组 64 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

暂无简介。

•1. memory complaint corroborated by a participant and an informant
•2. delayed recall score on the Seoul Verbal Learning Test (SVLT) at or below -1 standard deviations from the mean of the age and education-normative values among the Korean population
•3. Global CDR(Clinical Dementia Rating) score is 0.5, Memory CDR(Clinical Dementia Rating) score is 0.5 or 1.
•4. normal functional activities. S-IADL score :0-7
•5. Not diagnosed with dementia
•6. Modified Hachinski Ischemic Score (HIS): 0-4
•7. He/She can read and write
•8. 50 to 85 years of age
•9. brain magnetic resonance imaging or CT showing no clinical evidence of other diseases (i.e., normal pressure hydrocephalus, brain tumor, cerebrovascular disease) capable of producing cognitive impairment.
•10. written informed consent

•1. any patient who were involved in other clinical trials or treated with experimental drug within 4 weeks
•2. any patients with any severe or unstable medical disease that may prevent the patient from completing all study requirements (i.e., unstable or severe asthma or cardiovascular disease, active gastric ulcer, severe hepatic or renal disease)
•3. any patients with clinically significant laboratory abnormalities such as an abnormal thyroid function test, abnormal low level of vitamin B12 or folate, or positive venereal disease research laboratory test
•4. ny patients with any primary neurodegenerative disorder or psychiatric disorder other than AD (i.e., Parkinson's disease, schizophrenia, or major depressive disorder)
•5. any patiens with any history of drug or alcohol addiction during the past 10 years
•6. any hearing or visual impairment that can disturb the efficient evaluation of the patient

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