Effect of a 12-week cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment
- Conditions
- Mental and behavioral disorders
- Registration Number
- KCT0001385
- Lead Sponsor
- Dong-A University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 64
1. memory complaint corroborated by a participant and an informant
2. delayed recall score on the Seoul Verbal Learning Test (SVLT) at or below -1 standard deviations from the mean of the age and education-normative values among the Korean population
3. Global CDR(Clinical Dementia Rating) score is 0.5, Memory CDR(Clinical Dementia Rating) score is 0.5 or 1.
4. normal functional activities. S-IADL score :0-7
5. Not diagnosed with dementia
6. Modified Hachinski Ischemic Score (HIS): 0-4
7. He/She can read and write
8. 50 to 85 years of age
9. brain magnetic resonance imaging or CT showing no clinical evidence of other diseases (i.e., normal pressure hydrocephalus, brain tumor, cerebrovascular disease) capable of producing cognitive impairment.
10. written informed consent
1. any patient who were involved in other clinical trials or treated with experimental drug within 4 weeks
2. any patients with any severe or unstable medical disease that may prevent the patient from completing all study requirements (i.e., unstable or severe asthma or cardiovascular disease, active gastric ulcer, severe hepatic or renal disease)
3. any patients with clinically significant laboratory abnormalities such as an abnormal thyroid function test, abnormal low level of vitamin B12 or folate, or positive venereal disease research laboratory test
4. ny patients with any primary neurodegenerative disorder or psychiatric disorder other than AD (i.e., Parkinson's disease, schizophrenia, or major depressive disorder)
5. any patiens with any history of drug or alcohol addiction during the past 10 years
6. any hearing or visual impairment that can disturb the efficient evaluation of the patient
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Modified Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-cog)
- Secondary Outcome Measures
Name Time Method Controlled Oral Word Association Test ;Color-Word Stroop test;Digit symbol test;Korean Mini-Mental State Examination (K-MMSE);Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB);Korean version of the Alzheimer disease 8 (K-AD8);Korean version of the Geriatric Depression Scale-short form (SGDS-K) ;Subjective cognitive assessment;Brain metabolic change with brain PET-CT(Positron emission tomography);Story recall test;Digit span forward & backward;Controlled Oral Word Association Test (Animal)