Apomorphine Effects on Experimental Pain
- Registration Number
- NCT01744964
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter gene.
- Detailed Description
Healthy volunteers (n=105) participated in this randomized double-blind, placebo-controlled, cross-over trial. Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. A polymorphism (DAT-1) within the dopamine transporter gene (SLC6A3) was investigated.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
- healthy and free from chronic pain of any type did not use any medications other than oral contraceptives were able to understand the purpose and instructions of the study.
Exclusion Criteria
- any type of medical or painful condition use of medications or recreational drugs pregnancy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Saline Apomorphine Assessment of experimental pain models before and after treatment Apomorphine Apomorphine Assessment of experimental pain models before and after treatment
- Primary Outcome Measures
Name Time Method Cold pain tolerance 120 minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rambam Health Care Campus
🇮🇱Haifa, Israel