3D gait analysis and L-DOPA in Dravet syndrome.
Phase 4
Recruiting
- Conditions
- Dravet syndrome(severe myoclonic epilepsy in infant)Dravet syndrome, severe myoclonic epilepsy in infantD004831
- Registration Number
- JPRN-jRCTs041190116
- Lead Sponsor
- atsume Jun
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1.clinically diagnosed with Dravet syndrome
2.6 years or older, exhibiting gait deviations
3.adequately participation to 3D gait analysis with independent walk
4.written informed consent
Exclusion Criteria
1.unnable to participate to 3D gait analysis adequately
2.past prescription of L-DOPA
3.contraindication for L-DOPA
4.severe general complications
5.cannnot obtain informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gait Deviation Index at before and after L-DOPA administration
- Secondary Outcome Measures
Name Time Method Gait Profile Score, gait ability and QOL assessed by questionnaire at before and after L-DOPA administration<br>UPDRS score, FMDRS score<br>functional connectivities of basal ganglia network before and after L-DOPA adminiatration