JPRN-UMIN000024327
Completed
未知
An observational study of serum and cerebrospinal fluid concentrations of osimertinib for the treatment of lung cancer harboring EGFR activating and T790M mutations. - An observational study of serum and cerebrospinal fluid concentrations of osimertinib.
Conditionsung Cancer
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- ung Cancer
- Sponsor
- Miyagi Cancer Center
- Enrollment
- 40
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1\. Having an evidence of ILD or pulmonary fibrosis complication on chest X\-ray. 2\. With severe complication. 1\)Uncontrollable angina pectoris, myocardial infarction, or heart failure. 2\)Uncontrollable diabetes or hypertension. 3\)Severe infectious disease. 4\)gastrointestinal dysfunction with severe diarrhea. 3\. Impossible to take drugs orally. 4\. Inadequate case considered from drug package insert of osimertinib.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Plasma and cerebrospinal fluid concentrations treated with daily dose and high dose weekly erlotinib in non-small cell lung cancer patients with central nervous system metastasescentral nervous system metastases of non-small cell lung cancer with active EGFR mutations treated with daily dosing erlotinibJPRN-UMIN000004703Osaka City University10
Completed
Phase 4
Comparative plasma and cerebrospinal fluid pharmacokinetics of paracetamol following intravenous and oral administratioACTRN12615000322538Royal Melbourne Hospital21
Completed
Not Applicable
The study analyzing blood and cerebrospinal fluids from the patients with early onset Alzheimer disease to discover causative factors and biomarkersDiseases of the nervous systemKCT0000847Soon Chun Hyang University Hospital Bucheon516
Completed
Not Applicable
The value of biomarkers in cerebrospinal fluid in acute spinal cord injury as predictor of outcome.spinal cord injurytraumatic myelopathy10041543NL-OMON34689niversitair Medisch Centrum Sint Radboud30
Completed
Not Applicable
An investigation on spinal fluid in patients with sciatica-type or nerve-type pain of the lower limbeuropathic lower limb painNervous System DiseasesISRCTN34007592Trinity Translational Medicine Institute12