Comparative study of pretreatment with Lignocaine, Dexmeditomidine or Ketamine in providing relief from Propofol injection pain and withdrawal movements during induction of anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Degree of pain alleviation and withdrawal movements due to propofol injection during induction of anaesthesia
研究概览
简要总结
This study is a randomized, triple blinded and parallel group clinical trial comparing the efficacy of pretreatment with Lignocaine, Dexmeditomidine and Ketamine in providing relief from propofol injection pain and withdrawal movements during induction of aneasthesia for a period of 1 year in 96 patients.. It will be conducted at a tertiary care hospital in India. The primary outcome measures degree of pain alleviation and withdrawal movements due to Propofol injection during induction of anaesthesia using Lignocaine, Dexmeditomidine or Ketamine as pre treatment. The secondary outcome measures variations in hemodynamic parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients from 18-65 years undergoing elective surgical procedures under general anaesthesia using endotracheal intubation 2.American Society of Anaesthesiologist grade I and II
- •Body mass index less than 30kg/metre square.
排除标准
- •History of pulmonary, renal, hepatic, endocrine, neurological disease
- •Patients with cardiovascular diseases including hypertension on beta blockers, digitalis etc
- •Pregnant and lactating females
- •Patients on any sedatives or analgesics
- •Emergency surgical procedures 6.History of drug abuse or psychiatric illness
- •Hypersensitivity to study drugs
- •Subjects with anticipated difficulty in venous access.
结局指标
主要结局
Degree of pain alleviation and withdrawal movements due to propofol injection during induction of anaesthesia
时间窗: 6 months
次要结局
- Hemodynamic parameters(6 months)
研究者
Shivangi Sharma
Shri Bhausaheb Hire government medical college