TNFR2 Agonism and the Ex Vivo Expansion of Regulatory T Cells of Patients with Autoimmune or Inflammatory Disease

Recruiting

• Conditions: 'AAV'; 'Crohn's disease'; 'CD'; 'MS'; 'Systemic lupus erythematosus'; 'Multiple sclerosis'; 'SLE'; 'ANCA-associated vasculitides'; 10017969; 10003816

• Registration Number: NL-OMON50055
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients:
- Patient of the Maastricht University Medical Center (MUMC+) in Maastricht, The Netherlands, or of the Zuyderland Medical Center in Sittard-Geleen, The Netherlands
- Diagnosis of respective disease (MS, SLE, AAV, or IBD)
- Disease duration <5 years
- Ethnicity: Caucasian
- Untreated at the time of blood sampling or prednisone treatment of <10 mg/day
- Age: 18 * 65 years;Healthy Controls:
- Untreated at the time of blood sampling
- Ethnicity: Caucasian
- Age: 18 * 65 years

Exclusion Criteria

Patients:
- Proven infections two weeks prior to blood sampling
- Strong immunomodulation and/or immunosuppression in the last 3 months
- Other diseases: cancer (malignancies)
- Pregnancy;Healthy Controls:
- Proven infection two weeks prior to blood sampling
- Immune-related diseases
- Other diseases: cancer (malignancies)
- Pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified