Efficacy Evaluation of Avance QQ Collagen for Skin Beautification

Not Applicable

Completed

• Conditions: Skin Condition; Liposomal Encapsulation

• Registration Number: NCT06771388
• Lead Sponsor: TCI Co., Ltd.

Brief Summary

To assess Avance QQ Collagen product on skin condition improvement

Detailed Description

Not available

Study Timeline

• Study Start: 2024-11-01
• Study First Submitted: 2025-01-08
• Study First Submitted QC: 2025-01-08
• Study First Posted: 2025-01-13
• Primary Completion: 2025-01-24
• Study Completion: 2025-02-28
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Healthy male or female adults, age above 18 years old;
• The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023));
• Commitment not to use products having activity comparable with that of the product to be tested during the study period;
• Free of any dermatological or systemic disorder that would interfere with results.

Exclusion Criteria

• Subject with obvious skin surface damage;
• Subject who had oral or topical medication which may affect skin condition within 1 month;
• Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product;
• Female who is pregnant, nursing or planning to become pregnant during the course of the study;
• Received facial laser therapy, chemical peeling in the past 2 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The change of skin collagen density	Change from Baseline skin collagen density at 8 weeks	DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units
The change of skin wrinkles	Change from Baseline skin wrinkles at 8 weeks	VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: the amount of detectable wrinkles
The change of skin elasticity	Change from Baseline skin elasticity at 8 weeks	Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units

Secondary Outcome Measures

Name	Time	Method
The change of wrinkles around the eyes	Change from Baseline wrinkles around the eyes at 8 weeks	VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles
The change of skin hydration	Change from Baseline skin hydration at 8 weeks	Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.
The change of skin lightness	Change from Baseline skin lightness at 8 weeks	Chroma Meter MM500 was utilized to measure face skin lightness. Units: L\* index
The change of skin tone	Change from Baseline skin tone at 8 weeks	Chroma Meter MM500 was utilized to measure face skin color. Units: Individual Typology Angle (ITA°)

Trial Locations

Locations (1)

Chia Nan University of Pharmacy & Science; 🇨🇳 Pingtung, Taiwan