Brain kinetics of neurotransmission during THC intoxicatio

Completed

• Conditions: veranderingen in de hersenen; n.a.

• Registration Number: NL-OMON50329
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 62

Inclusion Criteria

*Occasional users:Used cannabis between 1 times a month and 1 times a week
during the previous year
*Chronic users: Used cannabis at least 3times/week during the previous year
*Age between 18 and 40 years
*Free from psychotropic medication
*Good physical health as determined by medical examination and laboratory
analysis
*Absence of any major medical, endocrine and neurological condition
*Normal weight, body mass index between 18 and 28 kg/m2
*Written Informed Consent

Exclusion Criteria

*History of drug abuse (other than the use of cannabis) or addiction
(determined by the medical questionnaire, drug questionnaire and medical
examination)
*Pregnancy or lactation
*Hypertension (diastolic> 90; systolic> 140)
*Current or history of psychiatric disorder (determined by the medical
questionnaire and medical examination)
*Liver dysfunction
*(Serious) side effects to previous cannabis use
*History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)
*For women: no use of a reliable contraceptive

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Neurotransmission of glutamate, GABA and dopamine, farmacokinetics of THC and<br /><br>subjective drug experiences.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>