Brain kinetics of neurotransmission during JWH-018 intoxicatio
- Conditions
- hersenkinetieknot applicable
- Registration Number
- NL-OMON53287
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 29
* Used cannabis between 1 time a month and 2 times a week during the previous
year
* Age between 18 and 40 years
* Free from psychotropic medication
* Good physical health as determined by medical examination and laboratory
analysis
* Absence of any major medical, endocrine and neurological condition as
determined by medical examination and laboratory analysis
* Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
* Written Informed Consent
* Good knowledge and understanding of the English language
* Participants must be willing to refrain from taking illicit psychoactive
substances during the study.
* Participants must be willing to drink only alcohol-free liquids and no
coffee, black or green tea, or energy drinks after midnight of the evening
before the study session, as well as during the study day.
* Participants must be willing not to drive a traffic vehicle or to operate
machines within 24 h after substance administration.
* History of drug addiction (determined by the medical questionnaire, drug
questionnaire and medical examination). * Pregnancy or lactation or pregnancy
planned during study participation. * Hypertension (diastolic > 90 mmHg;
systolic > 140 mmHg). * Current or history of psychiatric disorder (determined
by the medical questionnaire and medical examination). * Current presence or
history of psychosis in first-degree relatives * Any chronic or acute medical
condition. * History of cardiac dysfunctions (arrhythmia, ischemic heart
disease,*). * For women: no use of a reliable contraceptive. * Tobacco smoking
(>20 per day). * Excessive drinking (>20 alcoholic consumptions per week).
Furthermore, to participate in MRI scanning a few conditions need to be
satisfied by the subject. In the following cases, a MRI scan is not possible: *
The subject had an operation to his head or brain. * The subject has implanted
electronic devices, like a pacemaker. * The subject has an insulin pump under
his skin. * The subject suffers from epilepsy. * The subject suffers from
claustrophobia. * The subject has cardiological irregularities. * If there is a
chance that the subject might be pregnant. * If, apart from teeth fillings and
connectors, there are other metal parts in the body, like: o protheses o
implants o clips on blood vessels o metal parts in the eye o spiral o metal
braces o other metal objects In the following cases the researcher first needs
to establish, in collaboration with the participant, whether it would be
possible to have an MRI scan: * Subject has a tattoo (also permanent make-up).
* Subject has one or several piercings that cannot be removed. * Subject has a
metal wire behind his teeth.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the drug-induced change in neurotransmission of<br /><br>glutamate, GABA and dopamine which will be assessed by using MRS and resting<br /><br>state fMRI.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters include changes in attentional salience processing,<br /><br>memory, JWH-018 kinetics, metabolomics, and cytokines in blood and subjective<br /><br>experience of the drug effects, and drug liking and wanting.</p><br>