Observing Electrical Brain Responses during Processing of Nociceptive Stimuli around the Detection Threshold combined with a Cold Pressor Test: an Explorative Study
Completed
- Conditions
- Chronische pijn, centrale sensitisatie, perifere sensitisatiepain
- Registration Number
- NL-OMON48333
- Lead Sponsor
- niversiteit van Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Healthy subjects:
Age of 18 or above;
No history of pathological pain.
FBSS patients:
Age of 18 or above.
Exclusion Criteria
Patient*s refusal during the study;
Skin problems at the site of the pain sensitivity measurement;
Communication problems or incapable of following the instructions;
Pregnancy;
Consumption of alcohol or drugs within 24 hours before the experiment;
Pain complaints at the time of the experiment;
A medical history of chronic pain;
Unable to undergo pain sensitivity measurement;
Cardiac arrhythmias;
Heart valve defects;
Heart muscle diseases;
Open wound on the foot to be immersed;
Frequent caffeine use (>8 units/day);
Smokers (>5 cigarettes/day);
BMI > 30 kg * m-2;
Type 1 or 2 diabetes mellitus.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The nociceptive detection threshold<br /><br>EEG signals</p><br>
- Secondary Outcome Measures
Name Time Method <p>Current pain (NRS)<br /><br>Average pain in the lasts seven days (NRS)<br /><br>Questionnaire about symptoms of central sensitization: central sensitization<br /><br>inventory (CSI)<br /><br>Current medication intake<br /><br>Patient characteristics: age, sex, BMI<br /><br>Immersion time and water temperature<br /><br>Neurological evaluation<br /><br>FBSS duration (in months, patients only)<br /><br>pQST/PPDT</p><br>