Neural Bases of Post-stroke Emotion Perception Disorders

Recruiting

• Conditions: Stroke Sequelae; Emotions; Stroke

• Registration Number: NCT05595005
• Lead Sponsor: University Hospital, Lille

Brief Summary

This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.

Detailed Description

This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs healthy controls (2 groups of 40 subjects). It will include functional MRI, structural MRI (disconnectome), EEG, and behavioral assessments of emotion recognition and executive functions.

Study Timeline

• Study First Submitted: 2022-10-18
• Study First Submitted QC: 2022-10-21
• Study First Posted: 2022-10-26
• Study Start: 2024-02-16
• Status Verified: 2025-08
• Last Update Submitted: 2025-08-19
• Last Update Posted: 2025-08-24
• Primary Completion: 2025-10
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Stroke group:

• Man or Woman
• Age 18-80y
• Unique stroke, ischemic or hemorrhagic
• at the chronic phase (< 6 months)
• Written informed consent
• subject having a social insurance
• Subject who consent to complete all the study's experiments

Healthy controls group:

• Man or Woman
• Age 18-80y
• No history of neurological or psychiatric disease.

Exclusion Criteria

Stroke group

• Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
• History of other neurologic disorders
• Significant le vel of depression or anxiety, assessed by the STAI and the BDI questionnaires
• Non corrected visual loss
• Subjects suffering from visual neglect (assessed by the Bells Test and a bisection test (20mm)
• contra-indications to MRI
• pregnant or breastfeeding woman
• Women of childbearing age without effective contraception

Healthy controls group

• Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
• History of neurologic disorders
• Significant level of depression or anxiety, assessed by the STAI and the BDI questionnaires
• Non-corrected visual loss
• contra-indications to MRI
• pregnant or breastfeeding woman
• Women of childbearing age without effective contraception

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BOLD signal when fear visual recognition	1 day	Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = fear

Secondary Outcome Measures

Name	Time	Method
BOLD signal when happiness visual recognition	1 day	Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = happiness
Electrical connectivity (EEG) when fear visual recognition	1 day	Compare cerebral networks activated by a fear visual task recognition in both groups
Electrical connectivity (EEG) when fear happiness visual recognition	1 day	Compare cerebral networks activated by a happiness visual task recognition in both groups
Relationship between the behavioural performance in emotion recognition and executive functions	1 day	Correlation between behavioral performance in emotion recognition (Eckman Test) and executive functions (Stroop Test) in the stroke group
Relationship between emotional self-assessment and cerebral networks	1 day	Correlation between the ESQ (emotional state questionnaire) and cerebral connectivity (EEG) and fMRI networks
Relationship between lesion characteristics and the behavioral performance in emotion recognition	1 day	Correlation between lesion volume and the behavioural performance in emotion recognition (Eckman Test)
Electrical connectivity (EEG) when emotions auditory recognition	1 day	Compare cerebral networks activated by an auditory task recognition in both groups
Relationship between behavioral performance and cerebral networks	1 day	Correlations between fMRI and EEG networks vs. behavioral performance (emotion recognition)
Structural connectivity	1 day	Disconnectome maps in the stroke patients group

Trial Locations

Locations (1)

Hôpital Swynghedauw; 🇫🇷 Lille, France