NCT02285218Unknown不适用
Role of New Adipokines and Hepatokines in Prediction of Patients With Metabolic Syndrome or NAFLD
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- new adipokines
研究概览
简要总结
To investigate the predictive roles of adipokines and hepatokines to detect non-alcoholic fatty liver disease (NAFLD), diabetes, or dyslipidmia.
To examine the association or effects of clinical and biochemical factors (lab results and medication, etc.) on serum levels of adipokines and hepatokines in certain subjects with non-alcoholic fatty liver disease (NAFLD), diabetes, or dyslipidmia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •dyslipidemia
- •serum triglyceride≥150mg/dl, or taking medication to lower triglyceride levels (e.g. fibrates, niacin, omega-3, etc.) or
- •serum LDL-C≥100mg/dl, or taking medication to lower LDL-C levels (e.g. statin, ezetimibe, etc.)
- •type 2 diabetes
- •defined according to the ADA guideline (DM definition) or
- •taking any anti-diabetic medications
- •non-alcoholic fatty liver disease (NAFLD)
- •diagnosed as having fatty liver by ultrasonogram or
- •diagnosed as having fatty liver by transient elastogram (Fibroscan) or
- •diagnosed as having fatty liver by abdomina CT scan
- •Normal control
- •should not be included in other groups as above and
- •not taking any medication related to diabetes and dyslipidemia and
- •BMI <25kg/m2
排除标准
- •subjects who refused to agree with informed consents
- •subjects with organ-transplantation
- •serum creatinine ≥1.5mg/dl
- •pregnant women
- •liver cancer or pancreatic cancer
- •subjects with chronic hepatitis B or C virus infection
- •for NAFLD group, subjects with excessive alcohol consumption (men: ≥210g of alcohol per week, women: ≥140g of alcohol per week)
结局指标
主要结局
new adipokines
时间窗: To 8h fasting blood sample
several candidate adipokines and hepatokines to predict diseases will be measured using ELISA
new hepatokines
时间窗: To 8h fasting blood sample
several candidate adipokines and hepatokines to predict diseases will be measured using ELISA
次要结局
未报告次要终点
研究者
研究点 (1)
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