NCT05042167
Completed
Not Applicable
The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults
National Taiwan Normal University1 site in 1 country16 target enrollmentStarted: October 1, 2021Last updated:
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Changes in biomarkers of inflammation
Overview
Brief Summary
Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age: 20-80
- •Healthy male
- •Without experience of resistance training
Exclusion Criteria
- •No acute or chronic musculoskeletal symptoms
- •Alcohol or drug abuse
- •Fail to conduct resistance exercise
Outcomes
Primary Outcomes
Changes in biomarkers of inflammation
Time Frame: 24-hour during each study intervention
Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.
Secondary Outcomes
- Changes in glucose(24-hour during each study intervention)
- Changes in biomarkers of muscle damage(24-hour during each study intervention)
- Changes in complete blood count (CBC)(24-hour during each study intervention)
- Changes in metabolic parameters(24-hour during each study intervention)
- Changes in molecular markers in peripheral blood mononuclear cells (PBMC)(24-hour during each study intervention)
- Borgs Ratings of Perceived Exertion (RPE)(1-hour during each exercise intervention)
Investigators
Study Sites (1)
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