Effects of Resistance Exercise on Metabolic Responses

Not Applicable

Completed

• Conditions: Inflammatory Response
• Interventions: Other: Low-load resistance exercise; Other: High-load resistance exercise

• Registration Number: NCT05051306
• Lead Sponsor: National Taiwan Normal University

Brief Summary

Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-18
• Primary Completion: 2021-03-07
• Study First Submitted: 2021-08-30
• Study First Submitted QC: 2021-09-10
• Study First Posted: 2021-09-21
• Study Completion: 2021-12-31
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-14
• Last Update Posted: 2022-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• Age: 20-30
• Healthy male
• Without experience of resistance training

Exclusion Criteria

• No acute or chronic musculoskeletal symptoms
• Smoking
• Alcohol or drug abuse
• Fail to conduct resistance exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low-load resistance exercise	Low-load resistance exercise	4 low-load resistance exercises that target all major muscle groups.
High-load resistance exercise	High-load resistance exercise	4 high-load resistance exercises that target all major muscle groups.

Primary Outcome Measures

Name	Time	Method
Changes in TG	4-hour during each study intervention	TG mg/dL
Changes in uric acid	4-hour during each study intervention	uric acid mg/dL.
Changes in glucose	4-hour during each study intervention	glucose in mg/dL
Changes in insulin	4-hour during each study intervention	insulin in mU/L

Secondary Outcome Measures

Name	Time	Method
Changes in NO	4-hour during each study intervention	NO in µmol/L
Changes in biomarkers of inflammation	4-hour during each study intervention	Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL.
Changes in cortisol	4-hour during each study intervention	cortisol in ng/mL
Changes in complete blood count	4-hour during each study intervention	blood cell count in count per µL
Borgs Ratings of Perceived Exertion (RPE)	1-hour during each exercise intervention	Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).
Changes in lactate	4-hour during each study intervention	lactate in mmol/L
Changes in biomarkers of muscle damage	4-hour during each study intervention	Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.
Heart rate (HR)	6-hour during each study intervention	HR will be measured during each study intervention.
Changes in ET-1	4-hour during each study intervention	ET-1 in pg/mL
Visual Analogue Scale (VAS) of appetite	6-hour during each study intervention	Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being "not at all", 100 being "extremely").
Changes in biomarkers of appetite	4-hour during each study intervention	Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL.

Trial Locations

Locations (1)

National Taiwan Normal University; 🇨🇳 Taipei, Taiwan