Assessment of oral malodour and tonsil bacteria after gargling of throat with an antiseptic

Completed

• Conditions: Halitosis without periodontitis and otolaryngological disease.; Ear, Nose and Throat; Halitosis

• Registration Number: ISRCTN67671859
• Lead Sponsor: Aichi Gakuin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-19
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. To have visited the Aichi Gakuin University Dental Hospital and claiming oral malodour
2. No history of antibiotic use within the past 3 months
3. No history of otolaryngology consultation due to sinusitis, tonsillitis and tonsilloliths within the past 3 months

Exclusion Criteria

1) Otolaryngological disease at baseline
2) Periodontitis
3) To have used a gargle on the day of screening
4) A negative result for an organoleptic assessment (score 0)
5) Less than 26 ppb CH3SH in mouth air
6) Score of more than 30% on the Plaque Control Record

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparing the concentrations of VSC's (H2S, CH3SH, and CH3SCH3) in mouth air, measured using OralChroma, and organoleptic score, determined using the Rosenberg’s scale. Outcomes are measured at baseline and after 9 days.

Secondary Outcome Measures

Name	Time	Method
Outcomes are measured at baseline and after 9 days:<br>1. Concentrations of VSCs are measured using OralChroma. <br>2. Organoleptic assessment is judged on a 0–5 scale (Rosenberg’s scale).<br>3. Tongue coating score is recorded with Kojima’s scale.<br>4. Bacterial profiles are assessed by T-RFLP analysis.