Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects
Not Applicable
Recruiting
- Conditions
- Magnetic Resonance Imaging
- Interventions
- Diagnostic Test: T1rho imaging
- Registration Number
- NCT04993196
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution.
In this study we aim to characterise the normal appearance of T1rho in the brain parenchyma in healthy participants. T1rho values will be measured in normal brain structures.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Male and female volunteers greater than or equal to 18 years of age
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Exclusion Criteria
- Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy.
- Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis
- Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description T1rho MRI T1rho imaging -
- Primary Outcome Measures
Name Time Method T1rho value in normal grey and white matter in healthy volunteers Up to 2 months T1rho value (measured on T1rho weighted MRI) in normal grey and white matter in healthy volunteers
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CUHK
ðŸ‡ðŸ‡°Hong Kong, Hong Kong